Project Grant R21OD040020
- Federal Project Grant Award Summary The University of Pennsylvania received $812,443 in federal funding from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) to develop an engineered protein tag resource for live imaging and functional studies in zebrafish. The award, effective July 1, 2026 through March 31, 2030, encompasses development of a computational software package designed to identify optimal epitope tag...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $1,123,280 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 1, 2025, with a completion date of April 30, 2030. The research will be conducted in Durham, North Carolina, and focuses on elucidating the signaling and cellular mechanisms underlying notochord...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $114,458 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) effective August 1, 2025, with completion scheduled for July 31, 2027. This award funds research addressing the fundamental biological mechanisms underlying size memory during zebrafish appendage regeneration, with...
- Federal Project Grant Summary The University of Colorado-Denver received a $779,657 Project Grant award from the National Institutes of Health Office of the Director under the Research Infrastructure Programs (CFDA 93.351) on July 15, 2025, with completion anticipated by June 30, 2029. This award supports the establishment and expansion of community-accessible resources for site-directed transgenesis in zebrafish, a critical research model for studying vertebrate development, regeneration, and...
- Federal Grant Award Summary The National Institutes of Health Office of the Director awarded $722,774 to the University of Oregon under the Research Infrastructure Programs (CFDA 93.351) to develop a reproducible, community-driven sperm cryopreservation system for zebrafish genetic resources. The project, which commenced July 1, 2025, and runs through June 30, 2029, addresses a critical capacity gap in the biomedical research community. The Zebrafish International Resource Center (ZIRC)...
- Federal Project Grant Summary Duke University's Office of Research Administration received a $606,057 Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) awarded on September 24, 2025, with an ultimate completion date of August 31, 2029. The grant funds innovative data science and geospatial methods research designed to identify environmental drivers of disparities in hypertensive disorders of pregnancy...
- Federal Project Grant Award Summary Pennsylvania State University, operating as Penn State Milton S. Hershey Medical Center, received a $863,982 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) on August 15, 2025, with a completion date of July 31, 2029. The award funds development of a comprehensive 3D zebrafish microanatomical and gene expression atlas designed to advance disease modeling...
- Federal Project Grant Award Summary The National Institutes of Health Office of the Director is funding the University of Minnesota's development and dissemination of cryopreserved zebrafish embryo resources through the Research Infrastructure Programs (CFDA 93.351). Awarded on June 15, 2026, with $731,592 in federal obligations and a completion date of February 28, 2030, this project will develop standardized cryopreservation protocols for zebrafish embryos—a critical model organism in...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $804,342 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025, with completion targeted for June 30, 2030. The award funds basic biomedical research investigating the metabolic actions of glucagon beyond its canonical role in preventing...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $375,996 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026 through June 30, 2030. The award funds research to advance protein language models (PLMs)—computational tools that learn task-specific representations mapping protein sequences to functional outcomes. The research...
Duke University's Office of Research Administration is executing a research infrastructure project funded by the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351). This $444,125 award, which commenced July 1, 2026 and concludes June 30, 2028, supports the development of zebrafish tools for investigating enteroendocrine hormone biology. The project focuses on characterizing the structure and function of peptide hormones produced by enteroendocrine cells (EECs) in the gut epithelium—the body's largest endocrine organ—using zebrafish as a vertebrate model system. The research addresses significant knowledge gaps regarding hormone diversity, cellular targets, and endocrine circuit organization in both health and disease states. The deliverables include methodologies for visualizing EEC physiology in live zebrafish specimens, characterization of at least six distinct EEC subtypes with differentiated hormone transcript expression profiles, and mass spectrometry-based identification of functional peptide hormones. These research tools and findings are designed to advance fundamental understanding of enteroendocrine hormone biology with potential translational applications, particularly given the clinical relevance of hormones such as glucagon-like peptide-1 (GLP-1) in treating type 2 diabetes and obesity. The project outputs will provide the broader research community with validated zebrafish models and protocols applicable across multiple disease areas and research disciplines.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $444.1k | 6/26/26 |