The federal Project Grant award R21HD116006 for $270,000.00, awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research to elucidate the cellular and molecular mechanisms enabling spinal cord regeneration in zebrafish. The primary objectives are to: 1) Analyze cell state changes over time associated with successful versus failed spinal cord...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 "Child Health and Human Development Extramural Research", provides $561,640 to Duke University to conduct research on the signaling and cellular mechanisms that drive notochord patterning in zebrafish. The goal is to elucidate the clock mechanism that times the addition of new mineralized segments along the anterior-posterior axis, as well...
This federal Project Grant award of $294,408, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of Sonic Hedgehog signaling in regulating skeletal patterning during zebrafish fin regeneration. The research aims to identify key Sonic Hedgehog target genes and how they facilitate interactions between Sonic...
This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $147,486.00 to investigate the role of the KIF2C gene in regulating the microtubule cytoskeleton during the oocyte-to-embryo transition in zebrafish. The award period is from September 1, 2025 to August 31, 2028. The research aims to determine how KIF2C modulates...
This Project Grant award, valued at $107,458, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to investigate the mechanisms of double strand break repair in fetal male germ cells, which are precursors to spermatogonial stem cells that supply sperm throughout a male's reproductive lifespan. The research, to be conducted at Duke...
The Department of Health and Human Services (HHS) National Institutes of Health (NIH) awarded a $1,319,060 Project Grant to Duke University under the Trans-NIH Research Support (CFDA 93.310) program. The grant, effective September 1, 2023 through August 31, 2026, will fund research to study the robust formation of organs, with a focus on the development of the semicircular canals in the inner ear of zebrafish. The research aims to measure variations in tissue patterns, investigate the respective...
This federal Project Grant award for $169,000.00, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of a single-cell reference atlas of axolotl embryogenesis. The overarching goal is to elucidate the fundamental biological processes required for limb regeneration, with the aim of informing future regenerative medicine strategies for human limb injuries...
This $133,401 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), seeks to develop computational models that can identify the sequence of changes cells undergo during differentiation and maturation. The goal is to compare changes in gene expression and chromatin accessibility to understand how these modalities coordinate to drive cellular...
This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $142,997 to the University Corporation at Monterey Bay to conduct research on the interaction between migrating cells and their substrate during tissue development. The key objectives are to investigate the role of BMP signaling in substrate morphogenesis driven by...