Project Grant R21OD037653

Award Date 9/1/24
Completion Date 8/31/26
Dollars Obligated $266K
Funding Federal Agency
Office of the Director
Federal Grant Program
93.351
Assistance Type
Project Grant
Place of Performance
Bar Harbor, ME 04609, USA
Similar Awards
The federal Project Grant award, R21OD038406, was provided by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351). The $261,017 award will support the development of a mouse model system for targeted trimming of disease susceptibility loci. This innovative approach aims to streamline the identification of genes responsible for particular traits or diseases, as well as genes that affect the phenotypical presentation of primary mutations. The project...
The federal Project Grant award R24OD038114, totaling $775,888.00, was provided by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351). The grant will support the development and validation of a novel, modular CRISPR-ready HLA transgenic mouse platform at the La Jolla Institute for Immunology. This platform will allow researchers to rapidly generate HLA class I and II transgenic mouse models expressing specific HLA alleles relevant to a broad range of...
This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will support the development of a modular system for CRISPR genome and epigenome editing in mice. The $222,500 award to the Children's Hospital Corporation (doing business as Boston Children's Hospital) will fund the creation of mouse lines that express the core CRISPR Cas9 platforms, which can then be functionalized with various editing accessory proteins...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) provides $240,039 to Baylor College of Medicine to develop a novel mouse model for detecting genome editing events. The project aims to create an alternative "single-hit" strategy using CRISPR/Cas9 editing to activate a fluorescent reporter system in the existing AI9 transgenic mouse line. This new approach is expected to be more...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $844,954.00 to New York University School of Medicine to develop "Genomically Rewritten and Tailored Humanized Mouse Models for Various Organ Disorders." The 4-year project leverages "big DNA technology" to create advanced mouse models that accurately reflect human disease susceptibility and can be used to test cutting-edge therapies like...
This $1,211,545 Project Grant award from the National Science Foundation (CFDA 47.074 - Biological Sciences) will support the development of advanced Prime Editing (PE) systems in rice, tomato, and poplar plants. Prime Editing is a novel and highly versatile CRISPR-based gene editing technology that enables precise genome modifications. The key objectives of this 3-year project are to optimize Prime Editor proteins to increase their activity and editing efficiency, improve pegRNA structure and...
This federal Project Grant award, valued at $1,023,185 and provided by the National Institutes of Health under the Research Infrastructure Programs (CFDA 93.351), supports the development of conditional gene animal resources and precision genome editing tools for the zebrafish model organism. The primary awardee, Iowa State University, will expand the community resource for Cre recombinase-based conditional gene studies in zebrafish, covering embryonic development, major tissues, and...
This $293,550 federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) aims to establish the Acomys mouse as a new genetic platform for regeneration research. The funding will support the development of multiple genetic tools, including inbred lines, embryonic stem cells for chimeric and organoid analyses, and whole animal transgenesis techniques. These tools are intended to make the Acomys, a rodent species with...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $881,450 to the University of Massachusetts Medical School (UMass Medical) to develop novel humanized mouse models for engraftment of human tissue-specific macrophage populations. The objective is to generate genetically modified NSG mouse strains that are deficient in mouse tissue resident macrophages and express human cytokines to promote the development of...
The Jackson Laboratory was awarded a $718,404 Project Grant (CFDA 93.351 - Research Infrastructure Programs) by the National Institutes of Health to develop a new high-diversity outbred mouse population, the Wild Mouse Diversity Panel (WMDP), as a community resource for mouse genetics research. The project aims to create the WMDP from novel wild-derived inbred mouse strains, generate key genomic resources for the founder strains, and conduct phenotyping and gene mapping studies to demonstrate...

This federal Project Grant award, valued at $265,500.00 and provided by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351), aims to accelerate the rapid development of specialized mouse resource strains through the application of Prime Editing technology. The grant supports the Jackson Laboratory, a leading non-profit biomedical research institution, in optimizing Prime Editing strategies to efficiently create a diverse library of genetically engineered mouse models with a range of functional capabilities. Key aspects of the project include screening Prime Editing approaches in mouse cell cultures, establishing reagents to modify existing mouse strains with alternative genetic tags, and collaborating with the Johns Hopkins University to adapt Prime Editing methods for in vivo animal applications. This grant reflects the NIH's strategic initiative to advance biomedical research infrastructure and foster the development of cutting-edge research tools and technologies.

Generated 6/10/25, 4:09 AM