Project Grant R24OD036199
Award Date
7/15/24
Completion Date
6/30/28
Dollars Obligated
$881K
Funding Federal Agency
Office of the Director
Awarding Federal Agency
Aggregate Financial Assistance Data
Federal Grant Program
93.351
Assistance Type
Project Grant
Place of Performance
Worcester, MA 01655, USA
Similar Awards
This three-year, $8.29 million project grant from the National Institutes of Health National Institute on Aging will support the development of full human gene replacement mouse models of Alzheimer's disease. Funded under the Aging Research program (CFDA 93.866), the Regents of the University of Minnesota will generate mouse lines with replacement of key Alzheimer's-related genes, including APP, PSEN1, PSEN2, MAPT, APOE, TREM2, MS4A, and INPP5D, with their full human orthologues. Control...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $390,000 to The Medical College of Wisconsin, Inc. over a 5-year period from 2025 to 2029. The objective of this research project is to improve the foundational knowledge of immune cell biology in vivo, focusing on the ontogeny, kinetics, and function of tissue-resident macrophages. The researchers will utilize a novel small and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $243,713 to the University of Massachusetts Medical School to conduct research on how HIV-infected macrophages evade antibody-dependent cellular cytotoxicity (ADCC) mediated by natural killer (NK) cells. The research aims to characterize the effects of specific HIV accessory proteins on ADCC-triggered NK cell signaling towards infected CD4+...
This $407,000 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the University of Texas Rio Grande Valley (UTRGV) to investigate the relationship between HIV infection and the onset and progression of Alzheimer's disease (AD) using AD mouse models infected with a chimeric HIV strain. The central hypothesis is that HIV may accelerate the development of cognitive decline in AD. The 2-year study will conduct longitudinal behavioral,...
This $1,041,232 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to better understand the barriers to HIV eradication in lymph nodes and the gut. The primary awardee, The General Hospital Corporation (Massachusetts General Hospital), will use advanced imaging and omics technologies to characterize the cellular and molecular processes that impede immune-mediated elimination of HIV in...
The U.S. National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $415,815 Project Grant to the University of Nevada, Reno's Sponsored Projects Division to develop humanized microbiota mouse models of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
The key objectives of this two-year project are to: 1) Characterize and transplant stool samples from ME/CFS patients and healthy controls into...
This $475,369 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how microglia (the brain's resident macrophages) are programmed by the brain environment following transplantation.
The primary awardee, The Trustees of the University of Pennsylvania, will use single-cell RNA and ATAC sequencing to...
This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) in the amount of $131,922 will be used by the University of Oklahoma Univ Of Oklahoma Health Sciences Center Division to conduct research aimed at tracking inflammatory macrophage states in mouse models and identifying myeloid activation states associated with neuroinflammation and cognitive deficits in people living with suppressed HIV. The award, which runs from August 15,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $383,750.00 to the University of Nebraska Medical Center to explore the molecular, neuro-immune, and behavioral changes that occur during HIV-associated progressive aging. The research will utilize a long-term humanized mouse model to investigate how HIV latency and antiretroviral therapy (ART) contribute to premature aging and functional neuro-immune interactions at the molecular and...
This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, provides $4,563,558 under the Aging Research program (CFDA 93.866) to the Jackson Laboratory from September 15, 2022 to August 31, 2025.
The funding supports research to model the genetic interaction between the Klotho and ApoE alleles in Alzheimer's disease. Specifically, the awardee will characterize new mouse models harboring relevant human variants in both Klotho and ApoE to...