Project Grant R21OD037647
Award Date
5/1/25
Completion Date
4/30/27
Dollars Obligated
$240K
Funding Federal Agency
Office of the Director
Awarding Federal Agency
Aggregate Financial Assistance Data
Federal Grant Program
93.351
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
Similar Awards
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $844,954 to New York University School of Medicine to develop "Genomically Rewritten and Tailored Humanized Mouse Models for Various Organ Disorders". The project aims to leverage advanced DNA synthesis and editing technologies to create mouse models that accurately reflect human disease genetics and phenotypes. These "GREAT-GEMMS"...
This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $143,800.00 to Baylor College of Medicine to develop mouse models for functional studies of locus-specific DNA methylation. The project aims to create inducible CRISPR/Cas9 systems to precisely manipulate DNA methylation in vivo, enabling researchers to test the primary functional roles of DNA methylation and understand how epigenetic modifications...
This Project Grant award from the National Institutes of Health (NIH), under the Research Infrastructure Programs (CFDA 93.351), provides $775,888 to the La Jolla Institute for Immunology (LJI) to create and validate a modular CRISPR-ready HLA transgenic mouse platform. The goal is to develop a versatile mouse model that can be customized with different HLA class I and II alleles to study T cell responses across a broad range of diseases, from infectious diseases to cancer, autoimmune disorders,...
This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $265,500 to the Jackson Laboratory to rapidly develop mouse resource strains through the application of prime editing technology. The key objectives are to leverage prime editing, a novel CRISPR-based gene editing approach, to efficiently modify and functionally tag thousands of mouse genes without the need for labor-intensive microinjection methods. The...
This federal Project Grant award from the National Institutes of Health (NIH), under the Research Infrastructure Programs (CFDA 93.351), supports the development of a novel mouse model system for targeted trimming of disease susceptibility loci. The goal is to streamline the identification of causative genes within large susceptibility loci, enabling more efficient advancement of disease mechanism studies and therapeutic development. The $261,017 award, with a project period from May 1, 2025...
This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will fund the development of two novel mouse models at Cornell University. The $235,500 award, effective September 1, 2024 through June 30, 2026, will support the creation of a "unilateral mosaic" mouse model to study asymmetric disease pathology and a genetically-engineered mouse with a cell-tracing system to map cellular interactions in vivo. The...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) provides $330,025 to the University of Nebraska Medical Center (UNMC) to develop prototype mouse models for mRNA delivery and technology development. The objective is to explore the potential of the newly discovered SEND (Selective Endogenous Encapsidation for Cellular Delivery) cellular mRNA transfer process as a gene therapy delivery system. The award...
This R50 Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) provides $143,443 to Baylor College of Medicine to support a core facility offering comprehensive genetically engineered rodent model services for cancer research programs. The grant funds a highly experienced non-tenure track Research Specialist who serves as the Technical Director of the Genetically Engineered Rodent Models (GERM) Core. This Specialist generates various knockout, knockin and...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $881,450.00 to the University of Massachusetts Medical School (UMass Medical) to develop novel humanized mouse models for engrafting human tissue-specific macrophage populations. The goal is to generate NSG mouse strains that are deficient in mouse tissue resident macrophages and express human cytokines to promote the development of human myeloid cells,...
This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $240,750 to develop a new mouse model for targeting brown adipose tissue. The project aims to generate, validate, and make widely available a CRISPR/Cas9-engineered mouse model with Cre-recombinase expressed under the UCP1 promoter, allowing for efficient and safe targeting of mature brown adipocytes. The new mouse model is expected to have broad...