The National Institutes of Health (NIH) awarded a $265,500 Project Grant (CFDA 93.351 - Research Infrastructure Programs) to The Jackson Laboratory to rapidly develop a large-scale resource of genetically modified mouse strains. The key objectives are to leverage Prime Editing, a novel CRISPR-based technology, to efficiently insert functional DNA sequences into thousands of mouse genes that are already marked with a standardized tag. This will accelerate the creation of versatile mouse models...
This $881,450 Project Grant awarded by the National Institutes of Health (NIH) Office of the Director under the CFDA 93.351 Research Infrastructure Programs provides funding to the University of Massachusetts Medical School to develop novel humanized mouse models that efficiently support the engraftment and development of human tissue-resident macrophages. The project aims to genetically modify NSG mouse strains to reduce mouse macrophage populations and express human cytokines, enabling...
This $32,000,000 Project Grant was awarded by the Healthcare Systems Bureau, a civilian agency, on September 30, 2024 under the Congressional Directives program (CFDA 93.493). The grant recipient, Jackson Laboratory, is a nonprofit biomedical research institution that specializes in mammalian genetics and genomics research.
The funding will support the construction of facilities and the implementation of programs in Bar Harbor, Maine to advance biomedical research across diverse areas such as...
This Project Grant award from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) will support the development of two novel types of mouse models to study human diseases. The total funding amount is $235,500.00 and the award period runs from September 1, 2024 to June 30, 2026.
The first model, known as a "Unilateral Mosaic", will express disease-causing genes on only one side of the lung, creating both disease-prone and disease-resistant tissue...
The University of Wisconsin System was awarded a $217,533 Project Grant under the NIH Research Infrastructure Programs (CFDA 93.351) to generate a multi-color, multi-locus mouse reporter system capable of live tracking hematopoietic stem cells (HSCs) and multipotent progenitor cells (MPPs) in their native microenvironment. The project aims to address key limitations in current animal models by developing genetically engineered mice that can continuously visualize HSC/MPP dynamics and lineage...
This Project Grant award of $240,750 from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) supports the development, validation, and broad dissemination of a new mouse model for targeting brown adipose tissue. The key objectives are to:
Generate a novel CRISPR/Cas9-engineered mouse line that expresses Cre-recombinase under the control of the Ucp1 promoter, allowing for targeted manipulation of mature brown...
The Defense Health Agency awarded a $754,445 Project Grant to Jackson Laboratory, a nonprofit biomedical research organization, under the Military Medical Research and Development program (CFDA 12.420). The three-year award, effective August 15, 2023 through August 14, 2026, is funding research to target the cGAS-STING axis in order to limit inflammation and neuropathology associated with Gulf War Illness. Jackson Laboratory, located in Bar Harbor, Maine, has extensive experience conducting...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $2,462,651 to The Washington University for a 5-year project to comprehensively investigate the impact of genetic mutations known to cause neurodevelopmental and psychiatric disorders using over 100 mouse models.
The project, titled "Systematic and Scalable Phenotyping of Mouse Mutants for Neuropsychiatric Disease Genetics," seeks to...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include:
Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
This federal Project Grant award with ID R21OD037651, provided by the Office of the Director at the U.S. Department of Health and Human Services, supports the development and validation of a novel mouse model to study the role of mitochondrial dysfunction in a range of human diseases.
The $236,250 award, with a performance period from July 1, 2024 to June 30, 2026, will enable researchers at the University of Rhode Island to generate and characterize an inducible mitochondrial DNA mutator...
This $718,404 federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) supports the development of a new genetically diverse outbred mouse population, the Wild Mouse Diversity Panel (WMDP). The Jackson Laboratory, a nonprofit biomedical research institution, will initiate and maintain this outbred mouse population derived from novel wild-derived inbred strains of a single house mouse subspecies (Mus musculus domesticus). This new mouse resource is intended to expand the genetic diversity available in laboratory mouse models and enable investigations of natural genome complexity that were previously limited in existing inbred strains. The 4-year project period runs from April 2025 through March 2029 and will also generate key genomic resources for the founder mouse strains, as well as conduct proof-of-concept studies demonstrating the utility of the WMDP for translational research.