Project Grant 2428014

Award Date 11/1/24
Completion Date 10/31/27
Dollars Obligated $1.2M
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Penn State University, PA 16802, USA
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The key objectives of this 3-year project are to optimize Prime Editor proteins to increase their activity and editing efficiency, improve pegRNA structure and expression for single and multiplex prime editing, and modify plant DNA repair systems to enhance PE efficiency. By incorporating these innovative features and extensively testing them in both monocot and dicot plant species, the project aims to create highly efficient next-generation PE systems for precise genome editing applications in plant biology research and crop breeding. The project will also provide multidisciplinary research training for students and engage in outreach activities to educate the public on this cutting-edge genome engineering technology.

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