This federal Project Grant award from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) provides $1,023,185 to Iowa State University to expand the zebrafish research community's toolbox for conditional gene expression studies and improve precision genome editing techniques.
The key objectives are to: 1) develop new Cre recombinase-based conditional alleles for genes involved in epigenetics, mitochondrial biology, and other understudied areas; 2) further refine the GenEWELD and DonorGUIDE methods for precisely integrating long DNA fragments and short sequences into the zebrafish genome; and 3) continue disseminating these advanced genome editing resources to the broader zebrafish research community. Iowa State University is collaborating with Texas A&M AgriLife Research on the project, with the Texas institution focusing on improving the precision integration techniques. The project period runs from August 1, 2024 to July 31, 2028.
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