Project Grant R21NS148275
- This Project Grant award, valued at $184,506.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to investigate the dual role of amyloid beta (Aβ) in the neuropathogenesis of HIV-associated neurocognitive disorder (HAND). Specifically, the project aims to explore how Aβ influences HIV entry into the central...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,025,015 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Scintillon Institute in California. The grant, awarded on August 11, 2025, supports the development of a next-generation preclinical model of NeuroHIV that better recapitulates the neuro-immune-vascular system interactions in the context of antiretroviral therapy-mediated HIV suppression....
- This federal Project Grant award of $601,307 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to elucidate the mechanism by which HIV-1 downregulates specific RNA modifications (YW, DPH, and M1ACP3Ps) that normally repress ribosomal frameshifting on HIV-1 mRNA. The research aims to determine how this deregulation of RNA...
- This federal Project Grant award, worth $382,072, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to investigate the epigenetic mechanisms underlying HIV-associated neurocognitive disorders (HAND), which remain a significant complication of HIV infection despite antiretroviral therapy. The research will focus on characterizing the...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $698,390 to the Regents of the University of California at Riverside to conduct research aimed at harnessing innate immunity to control the neuroinflammatory HIV reservoir. The key objectives are to investigate how HIV infection triggers an interferon (IFN) response, how HIV...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $881,439 in funding to the University of North Carolina at Chapel Hill to conduct research on the evolution and latency of HIV in people infected with the subtype C virus. The key objectives of the project are to: determine the frequency of macrophage-tropic virus evolution in the central nervous system (CNS); identify which cell types in the CNS...
- This $823,691 Project Grant award was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to investigate the role of immune checkpoints in the central nervous system (CNS) of people living with HIV (PLWH) and their association with HIV-associated neurocognitive disorder (HAND). The research aims to determine the profiles and biological functions of soluble immune checkpoints (sICPs) in the CNS of PLWH and a simian immunodeficiency...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports research to investigate the relationship between HIV infection, aging, and cognitive decline. The $629,712 award to SRI International aims to leverage magnetic resonance imaging (MRI) and biomarker analysis to better understand how the brain's waste clearance system, known as the glymphatic system, may contribute to heightened risk of cognitive impairment in aging...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research on the role of cerebrospinal fluid (CSF) memory B cells in HIV-associated neuroinflammation and cognitive impairment. The $491,700 award to Yale University will fund a 2-year study to generate monoclonal antibodies from CSF-derived memory B cells in people with HIV on antiretroviral therapy, and screen them for reactivity against HIV,...
- This federal Project Grant award from the National Institutes of Health National Institute of Mental Health provides $6,499,884 to Yale University under the Mental Health Research Grants program (CFDA 93.242) to study the longitudinal nervous system consequences of SARS-CoV-2 in people with HIV-1 treated in early infection. The award will fund research from September 2022 to September 2025 to analyze pre- and post-COVID-19 data from a cohort of early antiretroviral therapy-treated people with...
This federal Project Grant award of $194,375.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), aims to determine the impact of persistent HIV in the central nervous system (CNS) on inflammation, brain structure and function, and cognition in people living with HIV. The primary goals are to: 1) Evaluate the specific contribution of HIV in the CNS to associations with inflammation, brain structure and function, and cognition, and 2) Examine whether detectable HIV RNA in the cerebrospinal fluid mediates the associations between these factors. The award was granted to the University of North Carolina at Chapel Hill, which has a demonstrated track record of executing complex federal research contracts and grants across biomedical sciences.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $194.4k | 7/30/25 |