This federal Project Grant award of $1,454,724 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to understand the mechanisms involved in HIV-1 latency in the central nervous system (CNS). The award aims to identify key factors, pathways, and regulators that determine the establishment, maintenance, and reactivation of latent HIV-1 virus in brain myeloid cell lineages, which are considered viral reservoirs in the...
The National Institutes of Health (NIH), through the Mental Health Research Grants program (CFDA 93.242) administered by the National Institute of Mental Health (NIMH), has awarded a $434,500 R21 grant to the University of California, San Diego (UCSD) to investigate the epigenetic mechanisms controlling HIV latency and neuropathogenesis in microglia. The project aims to use single-cell multi-omics approaches and state-of-the-art sequencing technologies to characterize the transcriptomic and...
The National Institute of Mental Health (NIMH) awarded a $985,984 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. (HJF) to determine the interplay between mucosal-associated invariant T (MAIT) cells and the translocated microbiome in HIV-induced neuroinflammation. The key objectives are to longitudinally compare the relationships between the gut microbiome, MAIT cells in cerebrospinal...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to evaluate social brain function in people living with HIV (PWH). The $733,355 award, effective March 1, 2025 through January 31, 2030, will utilize well-validated fMRI paradigms to examine neural circuits and performance related to two core social cognitive constructs: perceiving social cues (e.g., facial expressions, prosody) and...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a cluster randomized controlled trial to test the impact of a long-term, dynamic choice intervention on 12-month viral suppression among HIV clients experiencing treatment interruption in Malawi. The $653,677 award will be used to implement this research initiative over a project period from April 1, 2025 to January 31, 2030. The goal is to...
This federal Project Grant award, totaling $745,822.00 and provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of the PERK kinase in HIV-induced neuroinflammation and neurocognitive impairment (NCI) in people with HIV (PWH). The University of Pennsylvania, as the primary grantee, will use biochemical, cellular, and pharmacologic approaches to assess PERK's potential as a predictive...
The National Institute of Mental Health (NIMH) awarded a $780,447 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Brigham & Women's Hospital Inc. to test a differentiated service delivery model called CARES-DSD to improve engagement and viral suppression among people with HIV who have experienced treatment interruptions in South Africa. The 5-year project will recruit 300 participants from an ongoing study and evaluate the effectiveness of the CARES-DSD intervention compared...
The National Institute of Mental Health (NIMH) awarded a $1,300,224 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The Johns Hopkins University to conduct a study titled "HOMELINK2: Reducing Posthospitalization Mortality Among People Living with HIV Through Structured Home Care and Nutritional Supplementation." The project aims to evaluate the effectiveness of a home-based intervention involving structured post-hospitalization home visits with...
This federal Project Grant award from the National Institutes of Health National Institute of Mental Health provides $6,499,884 to Yale University under the Mental Health Research Grants program (CFDA 93.242) to study the longitudinal nervous system consequences of SARS-CoV-2 in people with HIV-1 treated in early infection. The award will fund research from September 2022 to September 2025 to analyze pre- and post-COVID-19 data from a cohort of early antiretroviral therapy-treated people with...
This $396,541 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to uncover fundamental mechanisms and key features governing the interactions between antiretroviral drugs (ARVs) and the blood-brain barrier (BBB) components. The overall goal is to improve the ability of ARVs to penetrate and treat HIV infection in the brain. The University of Colorado, as the prime awardee, will employ a physiologically...