Project Grant RF1MH132356
Award Date
9/16/22
Completion Date
9/15/25
Dollars Obligated
$6.5M
Federal Agency
National Institute of Mental Health
Awardee
Yale Univ (FL6GV84CKN57)
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Connecticut, USA
Similar Awards
This federal Project Grant award of $1,454,724 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to understand the mechanisms involved in HIV-1 latency in the central nervous system (CNS). The award aims to identify key factors, pathways, and regulators that determine the establishment, maintenance, and reactivation of latent HIV-1 virus in brain myeloid cell lineages, which are considered viral reservoirs in the...
This Project Grant award of $797,157 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research to understand the impact of post-acute sequelae of SARS-CoV-2 infection (PASC) on brain function and cognitive impairment. The research will be conducted by Yale University, leveraging their expertise in neuroscience, neuroimaging, and the established COVID Mind Study. The project aims to identify circuit-level brain...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to evaluate social brain function in people living with HIV (PWH). The $733,355 award, effective March 1, 2025 through January 31, 2030, will utilize well-validated fMRI paradigms to examine neural circuits and performance related to two core social cognitive constructs: perceiving social cues (e.g., facial expressions, prosody) and...
The National Institutes of Health National Institute of Mental Health awarded Yale University $7,389,444 under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2022 for a project concluding on August 31, 2025. The award will support Yale University in conducting a multivariate investigation to identify latent factors linking internalizing disorders such as anxiety, major depressive disorder, and posttraumatic stress disorder with COVID-19 outcomes including infection,...
This federal Project Grant award of $2,210,865, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to identify unique neural and inflammatory mechanisms of depression in people living with HIV (PLWH). The University of California, Los Angeles (UCLA) will conduct a cross-sectional study to enroll PLWH who are depressed and non-depressed, as well as HIV-negative subjects who are depressed and non-depressed. The research...
This federal Project Grant award, totaling $745,822.00 and provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of the PERK kinase in HIV-induced neuroinflammation and neurocognitive impairment (NCI) in people with HIV (PWH). The University of Pennsylvania, as the primary grantee, will use biochemical, cellular, and pharmacologic approaches to assess PERK's potential as a predictive...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA 93.242 Mental Health Research Grants program, will fund a 3-year research study on the structural, functional, and neurobehavioral consequences of COVID-19 infection during adolescence. The $183,096 award will support the principal investigator at the University of Maryland, Baltimore in conducting longitudinal neuroimaging, cognitive, and psychiatric assessments to evaluate the impact of SARS-CoV-2...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $384,772 to the University of Tennessee Health Science Center (UTHSC) to elucidate the cellular and molecular mechanisms by which SARS-CoV-2 infection alters neuronal activity and behavior in a mouse model. The research aims to determine how SARS-CoV-2 infection induces neuronal hyperactivity, activates microglia, and excites surrounding...
The National Institute of Mental Health (NIMH) awarded a $985,984 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. (HJF) to determine the interplay between mucosal-associated invariant T (MAIT) cells and the translocated microbiome in HIV-induced neuroinflammation. The key objectives are to longitudinally compare the relationships between the gut microbiome, MAIT cells in cerebrospinal...
The National Institutes of Health (NIH), through the Mental Health Research Grants program (CFDA 93.242) administered by the National Institute of Mental Health (NIMH), has awarded a $434,500 R21 grant to the University of California, San Diego (UCSD) to investigate the epigenetic mechanisms controlling HIV latency and neuropathogenesis in microglia. The project aims to use single-cell multi-omics approaches and state-of-the-art sequencing technologies to characterize the transcriptomic and...