Project Grant R01NS143478
- This federal Project Grant award of $194,375.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), aims to determine the impact of persistent HIV in the central nervous system (CNS) on inflammation, brain structure and function, and cognition in people living with HIV. The primary goals are to: 1) Evaluate the specific contribution of HIV in the CNS to...
- This Project Grant award, valued at $184,506.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to investigate the dual role of amyloid beta (Aβ) in the neuropathogenesis of HIV-associated neurocognitive disorder (HAND). Specifically, the project aims to explore how Aβ influences HIV entry into the central...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $698,390 to the Regents of the University of California at Riverside to conduct research aimed at harnessing innate immunity to control the neuroinflammatory HIV reservoir. The key objectives are to investigate how HIV infection triggers an interferon (IFN) response, how HIV...
- This federal Project Grant award, worth $382,072, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to investigate the epigenetic mechanisms underlying HIV-associated neurocognitive disorders (HAND), which remain a significant complication of HIV infection despite antiretroviral therapy. The research will focus on characterizing the...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,025,015 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Scintillon Institute in California. The grant, awarded on August 11, 2025, supports the development of a next-generation preclinical model of NeuroHIV that better recapitulates the neuro-immune-vascular system interactions in the context of antiretroviral therapy-mediated HIV suppression....
- This $418,625 Project Grant awarded by the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) to Drexel University supports research to develop a novel approach using RNA interference (RNAi) to silence HIV transcription in myeloid cells. The goal is to functionally eliminate the HIV reservoir in the central nervous system by inducing a stable heterochromatic state to block proviral transcription and production of new virions in chronically infected...
- This federal Project Grant award of $848,839 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to uncover new mechanisms by which HIV accessory proteins control natural killer (NK) cell function. The research aims to identify new NK cell ligands regulated by HIV infection and examine how changes to HIV accessory proteins like Nef and Vif impact the "missing self" trigger that drives NK cell...
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the dynamics and evolution of HIV Gag and GagPol processing. The $752,745 award aims to use molecular dynamics simulations, single-molecule FRET imaging, and cryo-electron tomography to probe the structure and dynamics of Gag and GagPol that enable ordered processing by the viral...
- This $624,902 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to investigate the impact of the HIV accessory protein Vpr on epigenetic remodeling and viral persistence in myeloid cells. The 5-year project, starting on Apr 23, 2025, will focus on characterizing how Vpr induces epigenetic changes to facilitate sustained HIV transcription and latency reactivation, as well as...
- This $147,486 Project Grant was awarded on January 10, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research by Case Western Reserve University to investigate how the N6-methyladenosine (m6A) RNA modification affects the post-transcriptional processing of human immunodeficiency virus (HIV) transcripts. The research aims to elucidate the role of m6A in the...
This federal Project Grant award of $601,307 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to elucidate the mechanism by which HIV-1 downregulates specific RNA modifications (YW, DPH, and M1ACP3Ps) that normally repress ribosomal frameshifting on HIV-1 mRNA. The research aims to determine how this deregulation of RNA modifications facilitates HIV-1 replication, inflammation, and neurotoxicity. The award is held by the University of Rochester and will fund this project over the period of September 24, 2025 to June 30, 2030. The findings from this research are expected to significantly improve the understanding of the molecular mechanisms behind HIV-1 replication and pathogenesis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $601.3k | 9/24/25 |