This federal Project Grant award, issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the role of the reactive glycolytic byproduct methylglyoxal (MG) in triggering early-onset neurological disorders in people living with HIV infection. The total award amount is $230,250, with a performance period from August 15, 2024 to June 30, 2026. The...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $818,886 to the University of California, San Diego (UCSD) to conduct epigenetic profiling and characterization of the HIV provirus and associated inflammation in the brains of people living with HIV. The 5-year project aims to leverage UCSD's expertise and access to the Last Gift rapid autopsy cohort to analyze frontal cortex and...
The National Institutes of Health (NIH), through the Mental Health Research Grants program (CFDA 93.242) administered by the National Institute of Mental Health (NIMH), has awarded a $434,500 R21 grant to the University of California, San Diego (UCSD) to investigate the epigenetic mechanisms controlling HIV latency and neuropathogenesis in microglia. The project aims to use single-cell multi-omics approaches and state-of-the-art sequencing technologies to characterize the transcriptomic and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Georgetown University provides $1,550,462 over 1 year starting September 30, 2024. The award supports a multidisciplinary study investigating the impact of Alzheimer's disease (AD) risk genes, particularly APOE E4, on brain function in a vulnerable population of HIV-positive older Black/African American adults. The study aims to enroll 120 HIV-positive participants (60 with and 60 without APOE...
This $823,691 Project Grant award was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to investigate the role of immune checkpoints in the central nervous system (CNS) of people living with HIV (PLWH) and their association with HIV-associated neurocognitive disorder (HAND). The research aims to determine the profiles and biological functions of soluble immune checkpoints (sICPs) in the CNS of PLWH and a simian immunodeficiency...
This Federal Project Grant award of $573,415 from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports research by the University of South Carolina to develop a regenerative "dendritic spine-targeted" therapeutic approach to address HIV-1-associated neurocognitive disorders (HAND) in older adults. The research aims to establish the efficacy of specific estrogen receptor B agonists (SERBAs) in restoring synaptodendritic integrity and mitigating...
This National Institute of Mental Health (NIMH) Project Grant award under the Mental Health Research Grants program (CFDA 93.242) provides $168,407 to The Washington University in St. Louis to investigate the relationship between biological aging and cognitive impairment in persons with HIV. The key objectives of the 5-year research project are to leverage measures of epigenetic age acceleration from DNA methylation and brain age acceleration from MRI imaging, combined with machine learning...
This $1,537,749 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to investigate the molecular mechanisms by which HIV and methamphetamine exposure activate the astrocyte-specific NLRP6 inflammasome, leading to neuroinflammation and associated neurological disorders in people living with HIV ("NeuroHIV"). The research utilizes in vitro, ex vivo, and in vivo approaches to elucidate the role of the...
This $843,177 federal Project Grant award is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports research to evaluate the efficacy of broadly neutralizing antibodies (bNAbs) encapsulated in nanocapsules for targeting HIV reservoirs in the central nervous system (CNS) of infants. The project aims to demonstrate improved delivery of bNAbs to the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $757,725 to the University of Rochester to conduct research on the role of monocyte delta-like 4 (DLL4) in cerebral small vessel disease and its impact on cognition in people with HIV. The key research objectives are to: 1) determine the role of monocyte-derived DLL4 in...