Project Grant R21NS143648
Award Date
6/7/25
Completion Date
5/31/27
Dollars Obligated
$461K
Federal Agency
National Institute of Neurological Disorders and Stroke
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Worcester, MA 01655, USA
Similar Awards
This federal Project Grant award, with ID R61NS140724, is provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $374,349 award supports the development and optimization of a new mouse model that accurately recapitulates the full spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This model is based on the discovery that...
This $251,250 federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the link between traumatic brain injury (TBI) and neurodegeneration in models of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) involving the TAR DNA-binding protein 43 (TDP-43). The research will characterize...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This $461,900 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project aimed at studying the role of the TDP-43 protein in causing structural deficits and muscle atrophy in amyotrophic lateral sclerosis (ALS). The primary awardee is Pennsylvania State University, which will work to identify TDP-43 translation targets in Drosophila muscles and validate them in fly models and patient tissue samples. This research seeks to uncover novel,...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $1,504,638 in funding to the University of Utah to conduct research on the role of the PASK kinase in modulating autophagy and TDP-43 proteinopathy as potential therapeutic targets for amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and spinocerebellar...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $427,625.00 to The Washington University in St. Louis, Missouri to develop novel cellular models for studying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The funded research will employ direct neuronal conversion techniques to generate...
The National Institute on Aging (NIA) awarded a $442,750 Project Grant (CFDA 93.866 - Aging Research) to Case Western Reserve University (CWRU) to develop synthetic replicas of TDP-43 filaments associated with frontotemporal dementia and other neurodegenerative diseases. The goal is to establish conditions for generating amyloid fibrils with structures identical to brain-derived TDP-43 filaments in vitro. This would provide a model for mechanistic studies on disease-relevant TDP-43 aggregation...
The National Institute on Aging awarded Case Western Reserve University $1,785,220 under the Aging Research program (CFDA 93.866) from May 2022 to April 2025. The university will research the role of deubiquitinase USP19 in the pathogenesis of TDP-43, a protein implicated in neurodegenerative diseases like frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Using mouse models, human post-mortem tissues, and molecular and cell biology techniques, the university aims to validate...
The University of Wisconsin System was awarded a $427,625 Project Grant under the National Institute on Aging's Aging Research program (CFDA 93.866) to develop a conditional, humanized mouse model for studying Ubiquilin 2 (UBQLN2)-associated Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The proposed research aims to generate the UBQLN2 mouse model, evaluate its neurodegenerative phenotypes, and utilize it to investigate disease pathways related to ALS/FTD caused by...
This federal Project Grant award of $3,727,176 from the National Institute on Aging's Aging Research Program (CFDA 93.866) will support research to investigate environmental risk factors linked to TDP-43 proteinopathies, which are associated with neurodegenerative diseases like frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The primary awardee, the University of North Carolina at Chapel Hill, will evaluate a high priority subset of environmental toxicants identified...