The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $374,349 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of North Carolina at Chapel Hill (UNC-CH) to develop and optimize a new animal model for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The project will leverage CRISPR technology to generate transgenic mice exhibiting key hallmarks of ALS/FTD, such as TDP-43...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is intended to support research characterizing novel mixed etiology dementia models with compromised TDP-43 function. The $210,310 award, which runs from June 2024 to October 2026, will enable The Johns Hopkins University to develop mouse models exhibiting Alzheimer's disease pathologies...
This National Institute on Aging (NIA) Project Grant award under the Aging Research Federal Grant Program (CFDA 93.866) in the amount of $787,095 provides funding for research to study the pathophysiological consequences of TAR-DNA binding protein 43 (TDP-43) pathology in oligodendrocytes (OLs) and its role in facilitating the spread of TDP-43 pathogenic species between glial and neuronal cells. The project, led by the Trustees of the University of Pennsylvania, aims to develop in vitro...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will provide $427,625 to The Washington University to develop a novel in vitro cellular model for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research aims to employ direct neuronal conversion of patient-derived fibroblasts, which preserves cellular age, as a tool to...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will investigate the synergistic relationship between the tau and TDP-43 proteins in the pathogenesis of Alzheimer's disease (AD). The $757,027 award, effective from January 1, 2025 to December 31, 2029, will utilize a C. elegans model to interrogate the mechanistic pathways underlying the interaction between tau and TDP-43 proteinopathies. The project aims to identify...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This $2,880,000 federal Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) will fund research by Baylor College of Medicine to uncover the role of extracellular condensates as triggers of neuroinflammation. The project aims to rigorously test the hypothesis that neuropathological proteins in diseases like amyotrophic lateral sclerosis and frontotemporal dementia hijack ancient immune signaling cascades to trigger...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $360,100 to The Washington University in St. Louis to conduct research on neuroinflammation and neurodegeneration related to TDP-43 pathology. The key objectives are to:
Determine the genetic and cellular regulators of phosphatidylserine exposure and neuroimmune cell activation.
Test the degree to which ATP8A2 deficiency exacerbates neurodegenerative phenotypes observed in TDP-43...
This $1,029,657 Project Grant awarded by the National Institute on Aging (NIA), part of the Aging Research Federal Grant Program (CFDA 93.866), supports research into the role of TDP-43 mislocalization, structure, and post-translational modifications in frontotemporal lobar degeneration (FTLD-TDP) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC).
The award aims to investigate the molecular mechanisms underlying the region-specific accumulation of...
This $460,625 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support the development of mutant-specific antisense oligonucleotides (ASOs) as potential therapeutics for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
The key objectives are to: 1) Design and evaluate allele-specific ASOs targeting the...