This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, aims to develop and optimize a new animal model for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The award will provide $374,349 to the University of North Carolina at Chapel Hill to establish a mouse model based on TDP-43 acetylation, which has...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This $251,250 federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the connection between dysfunction of neuroimmune-related processes and amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) disorders. The research will use a mouse model of mutant TDP-43, a key pathological protein...
The National Institute on Aging awarded Case Western Reserve University $1,785,220 under the Aging Research program (CFDA 93.866) from May 2022 to April 2025. The university will research the role of deubiquitinase USP19 in the pathogenesis of TDP-43, a protein implicated in neurodegenerative diseases like frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Using mouse models, human post-mortem tissues, and molecular and cell biology techniques, the university aims to validate...
This $1,157,896 Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research at Brown University focused on elucidating the mechanistic basis of transketolase-mediated suppression of neurodegeneration in amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). The grantee will study multiple models of ALS/FTD using Drosophila genetics and analyze molecular readouts such as redox state, autophagy,...
The University of Florida was awarded a $3.86 million Project Grant from the National Institute on Aging, part of the National Institutes of Health within the Department of Health and Human Services. The grant falls under the Aging Research program (CFDA 93.866), which supports biomedical, social and behavioral research on aging. The three-year grant will fund research to test the hypothesis that novel types of repeat-associated non-AUG (RAN) proteins contribute to amyotrophic lateral...
This three-year, $8.29 million project grant from the National Institutes of Health National Institute on Aging will support the development of full human gene replacement mouse models of Alzheimer's disease. Funded under the Aging Research program (CFDA 93.866), the Regents of the University of Minnesota will generate mouse lines with replacement of key Alzheimer's-related genes, including APP, PSEN1, PSEN2, MAPT, APOE, TREM2, MS4A, and INPP5D, with their full human orthologues. Control lines...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $427,625 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853) to The Washington University in St. Louis. The research project aims to develop a novel cellular model for investigating the mechanisms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) using directly converted neurons derived from patient...
This federal Project Grant award of $538,380, provided by the National Institute on Aging (CFDA 93.866 Aging Research program), supports research by the Vlaams Instituut Voor Biotechnologie (VIB) in Gent, Belgium to investigate the genetic mechanisms underlying frontotemporal lobar degeneration (FTLD), a type of dementia. The key objectives are to: 1) develop a humanized FTLD-TDP mouse model by transplanting patient-derived microglia into mice overexpressing the TMEM106B risk gene; 2) identify...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $219,930 to the University of Wisconsin - Madison to develop a new high-throughput assay to measure the formation of amyloid-beta oligomers, which are of significant interest for Alzheimer's disease research. The project aims to create a genetically encoded sensor that can detect oligomer formation and report it through gene expression, enabling rapid, large-scale studies of the factors...