Project Grant R21AG093032

Award Date 5/1/25
Completion Date 4/30/27
Dollars Obligated $462K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Hershey, PA 17033, USA
Similar Awards
This $251,250 federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the connection between dysfunction of neuroimmune-related processes and amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) disorders. The research will use a mouse model of mutant TDP-43, a key pathological protein...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, aims to develop and optimize a new animal model for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The award will provide $374,349 to the University of North Carolina at Chapel Hill to establish a mouse model based on TDP-43 acetylation, which has...
This federal Project Grant award of $1,671,813.00 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports biophysical and pathophysiological studies of the interaction between TDP-43 and tau proteins. The University of Florida is the primary grantee, with a sub-award to Central Michigan University to provide expertise in Drosophila genetics, molecular biology, biochemistry, and microscopy to examine the role of tau and TDP-43 in neurodegenerative disease. The project...
This federal Project Grant award of $787,095 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by The Trustees of the University of Pennsylvania to study the pathophysiological consequences of TAR-DNA binding protein 43 (TDP-43) aggregation in oligodendrocytes and its role in the spread of TDP-43 pathology in neurodegenerative diseases. The project aims to develop in vitro models to investigate the effects of TDP-43 pathology in oligodendrocytes and evaluate...
This $1,938,189 Project Grant award was made by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to Emory University in Atlanta, Georgia. The project aims to expand understanding of the role of chimeric dipeptide repeat proteins (CDPRs) in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) caused by the C9ORF72 gene mutation. Key objectives include: 1) Identifying the complexity, extent, and mechanism of CDPR pathology in...
This $1,157,896 Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research at Brown University focused on elucidating the mechanistic basis of transketolase-mediated suppression of neurodegeneration in amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). The grantee will study multiple models of ALS/FTD using Drosophila genetics and analyze molecular readouts such as redox state, autophagy,...
The National Institute on Aging awarded Case Western Reserve University $1,785,220 under the Aging Research program (CFDA 93.866) from May 2022 to April 2025. The university will research the role of deubiquitinase USP19 in the pathogenesis of TDP-43, a protein implicated in neurodegenerative diseases like frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Using mouse models, human post-mortem tissues, and molecular and cell biology techniques, the university aims to validate...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $757,027 to the University of Washington to conduct research on the mechanisms underlying the synergistic relationship between tau and TDP-43 proteins in Alzheimer's disease (AD). The 5-year project, starting January 1, 2025, aims to investigate how the combination of tau and TDP-43 pathologies impairs the lysosomal autophagy pathway, which is a compensatory mechanism observed in AD. The...
This $404,058 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to identify novel small molecules that can stabilize functional, multimeric forms of the TDP43 protein to restore its normal RNA binding and splicing regulation activities. TDP43 dysfunction is a key pathological feature in frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and other neurodegenerative "TDP43 proteinopathies". The research team at the Regents of...

This $461,900 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to study the mechanisms by which the protein TDP-43 impacts muscle structure and function in amyotrophic lateral sclerosis (ALS) and related neuromuscular disorders.

The research aims to identify how TDP-43 alters the translation of specific mRNA targets in muscle cells, and how these changes may contribute to muscle atrophy observed in ALS patients. The project will first use Drosophila models to identify TDP-43 translation targets in muscle, then validate the key candidates in fly muscle and patient tissue samples. These studies are expected to uncover novel, muscle-specific therapeutic targets for TDP-43 proteinopathies and related neuromuscular diseases. The award period is from May 1, 2025 to April 30, 2027 and the work will be conducted by the Pennsylvania State University Hershey Medical Center.

Generated 5/13/25, 5:43 AM