Project Grant R21AG094047

Award Date 5/15/25
Completion Date 4/30/27
Dollars Obligated $443K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Cleveland, OH 44106, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research effort to identify novel small molecules that can stabilize functional TDP43 multimers and restore TDP43 activity. The $404,058 grant, with a performance period from May 1, 2025 to April 30, 2027, will fund the development of a high-throughput screening pipeline to screen compound libraries and discover molecules that can prevent the loss of TDP43's native function. The research...
The National Institute on Aging awarded Case Western Reserve University $1,785,220 under the Aging Research program (CFDA 93.866) from May 2022 to April 2025. The university will research the role of deubiquitinase USP19 in the pathogenesis of TDP-43, a protein implicated in neurodegenerative diseases like frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Using mouse models, human post-mortem tissues, and molecular and cell biology techniques, the university aims to validate...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $757,027 to the University of Washington to support research on the synergistic relationship between tau and TDP-43 proteins in Alzheimer's disease (AD). The award period is from January 1, 2025 to December 31, 2029. The key objectives are to: 1) further investigate the mechanistic pathways by which tau and TDP-43 may interact to exacerbate proteotoxicity in AD, focusing on the lysosomal...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Regents of the University of California, San Francisco (UCSF) provides $1,275,512 in funding over 2 years from June 1, 2025 to May 31, 2027. The objective is to determine how different forms of the protein progranulin (PGRN) impact the accumulation of the TDP-43 protein, which is associated with neurodegenerative diseases like Alzheimer's, frontotemporal dementia, and limbic-predominant...
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This Project Grant award, R21AG094047, was provided by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The $442,750 award, with a period of performance from May 2025 to April 2027, supports research by Case Western Reserve University (CWRU) to develop synthetic replicas of TDP-43 protein filaments associated with frontotemporal dementia and amyotrophic lateral sclerosis. The goal is to establish an experimental model for generating these disease-relevant protein aggregates in vitro, which would enable further mechanistic studies and the development of potential diagnostic tools and therapeutics targeting TDP-43 proteinopathies. This work represents an important advancement in understanding the structural features and aggregation pathways of TDP-43, a key pathological hallmark of several neurodegenerative diseases.

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