This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to develop a novel cellular model for investigating amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will directly convert patient-derived fibroblasts into neurons, preserving the epigenetic age of the starting cells, in order to...
This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
This $1,157,896 Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research at Brown University focused on elucidating the mechanistic basis of transketolase-mediated suppression of neurodegeneration in amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). The grantee will study multiple models of ALS/FTD using Drosophila genetics and analyze molecular readouts such as redox state, autophagy,...
This $2,307,075 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports an ambitious research program at The Leland Stanford Junior University. The funded research aims to define novel mechanisms underlying human neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Parkinson's disease, and...
This $460,625 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate the roles of the deubiquitylation pathway in TDP-43 pathology related to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The award, provided to the University of Massachusetts Medical School, will utilize mouse models and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research into the role of TDP-43 dysfunction and neuroinflammation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The $251,250 award, active from April 1, 2025 to March 31, 2027, will enable investigations using a mouse model of mutant TDP-43 as...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $374,349 to the University of North Carolina at Chapel Hill to develop and optimize a new animal model for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research aims to establish a mouse model that accurately recapitulates the human disease...
This $224,140 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for a project titled "Understanding the Relationship Between Cortical Hyperexcitability and the Progression of FTD/ALS Pathology and Behavioral Deficits in Mice". The grant aims to elucidate the mechanisms of circuit dysfunction in frontotemporal dementia (FTD)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $630,496 to the J. David Gladstone Institutes in San Francisco, CA to conduct research on the proteostasis, neuroinflammation, and neurodegeneration mechanisms involved in frontotemporal dementia (FTD) caused by GRN haploinsufficiency. The key objectives are to better define the alterations in proteostasis, autophagy/lysosomal function, and TDP-43 turnover in FTD neurons, microglia, and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,841,367.00 to The Regents of the University of California, San Francisco to conduct research on understanding the role of the TBK1 protein kinase in regulating selective autophagy pathways in neurons. The goal is to gain a comprehensive understanding of how disruption of TBK1 function leads to the loss of excitatory neurons, which is a key feature of frontotemporal dementia (FTD)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and closely related, but unaffected, cortical neurons. They will conduct this analysis in mouse models of ALS-FTD as well as in human iPSC-derived "assembloids" that model the cortico-spinal circuitry. The goal is to identify subcellular molecular alterations that may render specific neuronal subtypes more susceptible to degeneration in these neurodegenerative diseases. The project period runs from Sep 1, 2023 to Aug 31, 2026.