Project Grant R21NS137258
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $426,057 in funding to Duquesne University to evaluate the response of oligodendrocyte precursor cells (OPCs) during a viral infection in the developing brain. The project aims to define the protective role of juvenile immune cells in promoting OPC proliferation and the...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $576,142 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Oregon Health & Science University (OHSU) on June 19, 2025. The grant supports research focused on understanding the molecular and genetic mechanisms governing oligodendrocyte development and myelination in the central nervous system. Key objectives include defining the cellular...
- This Project Grant award of $566,382 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research at Temple University to investigate strategies for overcoming the inhibitory mechanism of "synaptic arrest" by oligodendrocyte precursor cells (OPCs) that restricts regeneration of sensory axons in the spinal cord after dorsal root injury. The...
- This Project Grant award of $426,650 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research conducted by Trustees of Tufts College in Medford, MA. The goal of the project is to develop a hybrid strategy to efficiently derive high-purity, region-specific cell populations, particularly oligodendrocytes (OLs) and neural crest progenitors (NCPs), from...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders provides $543,337 to Vanderbilt University to conduct research on long-distance regressive signaling in nervous system development. The research aims to characterize the features of the p75 neurotrophin receptor (p75NTR) in regressive signaling processes like apoptosis, axon degeneration, and...
- This $440,275 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is focused on systematically discovering upstream regulators of the OLIG2 transcription factor, which plays a critical role in central nervous system myelination by oligodendrocytes. The key objectives are to determine the role of the newly identified regulator MEF2D in OLIG2 expression...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is providing $426,938 to Virginia Commonwealth University to explore the role of a novel glutamate-driven signaling pathway initiated in maturing oligodendrocytes through the glutamate transporter GLT-1/EAAT2. This research aims to characterize the mechanisms downstream of...
- This $635,386 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Duke University to investigate the pathogenic mechanisms of inflammatory subventricular zone injury in preterm infants. The research aims to elucidate how complications of prematurity, such as intestinal perforation, can lead to diffuse myelination deficits and...
- This $451,822 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research by Oregon Health & Science University (OHSU) to determine the distinct molecular profiles and functions of "pioneer" and "follower" neurons during nervous system development. The project aims to leverage single-cell RNA sequencing to identify...
- This Project Grant award of $411,734.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of endothelin signaling in regulating adult neural stem cell behavior, particularly in the context of demyelination and remyelination. The key research objectives are to: 1) determine how endothelin-1 signaling maintains neural stem cell...
P75NTR REGULATES OLIGODENDROCYTE PROGENITOR DEVELOPMENT IN THE SUBVENTRICULARZONE OF POSTNATAL RATS - SUMMARY GENERATING THE APPROPRIATE NUMBERS OF CELLS IN A PARTICULAR LINEAGE IS CRITICAL FOR NORMAL DEVELOPMENT OF THE BRAIN. PROGENITOR CELLS OF BOTH NEURONAL AND GLIAL LINEAGES ARE PRESENT IN THE POSTNATAL SUBVENTRICULAR ZONE (SVZ) OF RATS, WITH A PERIOD OF GLIOGENESIS THAT IS MAXIMAL DURING THE FIRST TWO POSTNATAL WEEKS. WE FIND THAT THE P75 NEUROTROPHIN RECEPTOR (P75NTR) IS ABUNDANTLY EXPRESSED IN INTERMEDIATE PROGENITOR CELLS IN THE RAT SVZ. DELETION OF THIS RECEPTOR ELICITS AN OVERPRODUCTION OF OLIGODENDROCYTE LINEAGE CELLS AND PRECOCIOUS MATURATION OF THESE CELLS WITH ABNORMAL MYELIN DEVELOPMENT DURING THE EARLY STAGES OF MYELINATION, SUGGESTING THAT P75NTR NORMALLY ACTS TO RESTRICT PREMATURE DIFFERENTIATION OF OLIGODENDROCYTE LINEAGE CELLS. THIS EXPRESSION OF P75NTR IN THE SVZ HAS BEEN OBSERVED IN RAT AND HUMAN, BUT NOT MOUSE, AND WE SUGGEST THAT THIS MAY BE A MECHANISM THAT EVOLVED TO REGULATE THE TIMING AND BALANCE BETWEEN GENERATING CELLS OF A PARTICULAR LINEAGE WHILE MAINTAINING A POOL OF PROGENITOR CELLS IN AN IMMATURE STATE. WE WILL CREATE A CELL-SPECIFIC RAT LINE TO DELETE P75NTR (P75NTRFL/FL) SPECIFICALLY IN OLIGODENDROCYTE PROGENITORS (PDGFRA-CREERT2), AND USE THIS LINE AS WELL AS THE GLOBAL P75NTR KO RATS TO INVESTIGATE MECHANISMS BY WHICH P75NTR REGULATES OLIGODENDROCYTE DIFFERENTIATION AND MATURATION. ADDITIONALLY, WE WILL DETERMINE WHETHER DELETION OF P75NTR IMPACTS THE PERSISTENCE OF THE OLIGODENDROCYTE PROGENITOR POOL IN THE SVZ. WE WILL ASSESS WHETHER THE ALTERED REGULATION OF OLIGODENDROCYTE PROGENITORS DURING DEVELOPMENT IN THE P75NTR KO RATS IMPACTS THE ABILITY TO REMYELINATE AFTER A DEMYELINATING LESION IN ADULT RATS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $196.3k | 6/9/25 | ||
| Not listed | $235.5k | 7/1/24 | ||
| Not listed | $235.5k | 7/1/24 |