Project Grant R01NS140152
- This federal Project Grant award of $629,031.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a novel label-free, live-cell classification system for neural stem cell activation state. The award aims to leverage fluorescence-lifetime imaging (FLIM) and analysis of cellular metabolites and autofluorescence to non-invasively track neural...
- This federal Project Grant award of $458,189 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research focused on understanding how specific membrane-remodeling factors regulate oligodendrocyte membrane dynamics and myelination in the central nervous system. The research aims to elucidate the mechanisms by which these factors shape...
- This federal Project Grant award in the amount of $426,650 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports research by Trustees of Tufts College, doing business as Tufts University, to develop a hybrid strategy for efficiently deriving region-specific neural cell populations, including oligodendrocytes and neural crest progenitors,...
- This federal Project Grant award of $427,104.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on identifying biomarkers of demyelination and remyelination in a mouse model of multiple sclerosis (MS). The key objectives are to profile proteins and lipids in tissue-derived and plasma-derived extracellular vesicles to discover novel biomarkers...
- This Project Grant award of $427,625 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is funding research to develop a toolbox for studying proteome plasticity in brain endothelial cells. The research aims to further understand the mechanisms of brain blood flow regulation, which is critical for addressing neurological disorders like Alzheimer's disease where disruption of...
- This $397,500 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program is supporting research to study the fundamental principles linking neurodevelopmental processes to the functional organization of neural circuits. The goal is to understand how these principles could enable network-scale regeneration of the nervous system, which is a key medical...
- This $536,617 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research conducted by Oregon Health & Science University (OHSU) to understand the mechanisms of adult neural regeneration using planarian and zebrafish model organisms. The research aims to elucidate how adult stem cells can generate the appropriate diversity of...
- This $614,009 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research into the molecular mechanisms of oligodendrocyte myelination and remyelination, which are critical processes for addressing demyelinating diseases of the central nervous system like multiple sclerosis. The awardee, Children's Hospital...
- This federal Project Grant award of $484,125 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research conducted by Trustees of Dartmouth College to investigate how disruptions in mitochondrial dynamics within oligodendrocyte precursor cells impact their fate and the survival of mature oligodendrocytes. The research aims to provide insights into the...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded Kenyon College a Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $454,424 grant, effective April 1, 2025 through March 31, 2028, aims to characterize the cellular and molecular mechanisms of Schwann cell demyelination and identify factors that promote peripheral remyelination using a novel larval zebrafish model. The project will test...
This federal Project Grant award of $411,734.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research into the role of endothelin signaling in adult neural stem cell homeostasis and remyelination. The goal is to determine how endothelial cell-derived endothelin-1 regulates neural stem cell quiescence and differentiation, and to understand its impact on neural stem cell-mediated remyelination following demyelination. Specifically, the researchers at the University of Notre Dame will use conditional knockout mice and primary cell culture to investigate endothelin-1 signaling in the healthy adult mouse brain, as well as in a cuprizone-induced demyelination model, to elucidate the mechanisms by which this pathway maintains adult neural stem cell quiescence and impacts remyelination. The award period extends from August 6, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $411.7k | 8/6/25 |