This federal Project Grant award of $614,009, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research aimed at understanding the molecular mechanisms of oligodendrocyte myelination and remyelination. The research, conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, focuses on identifying critical factors that promote myelin...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of membrane-remodeling factors in regulating oligodendrocyte morphology and central nervous system (CNS) myelination. The $458,189 award to the University of Texas Medical Branch at Galveston will fund a 5-year project to (1) identify...
This federal Project Grant award of $426,650 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to develop a hybrid strategy for rapidly generating region-specific neural progenitor cells and oligodendrocytes from human pluripotent stem cells. The grant, awarded to Trustees of Tufts College, will focus on leveraging Sox10 transcription factor induction to efficiently...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the pathogenic mechanisms of inflammatory subventricular zone injury in preterm infants. The $635,386 award to Duke University aims to define immune signatures associated with the development of subventricular zone echogenicity in preterm infants with...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $443,354 to the University of Pittsburgh to conduct research on targeting the hexosamine biosynthetic pathway in pediatric brain tumors, specifically diffuse midline gliomas (DMG) harboring the H3K27M mutation. The research aims to investigate how this metabolic pathway supports tumor growth...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the effects of pediatric traumatic brain injury (PTBI) and early life stress on the development of the prefrontal cortex and resulting cognitive function. The $148,700 award to The Ohio State University aims to define acute neuroimmune changes in the...
This $475,369 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how microglia (the brain's resident macrophages) are programmed by the brain environment following transplantation. The primary awardee, The Trustees of the University of Pennsylvania, will use single-cell RNA and ATAC sequencing to...
This $440,275 Project Grant, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to systematically discover upstream regulators of the OLIG2 transcription factor, which plays a central role in oligodendrocyte lineage specification and central nervous system myelination. The award was granted to The Research Foundation For The State...
This federal Project Grant award of $221,120.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to improve neural progenitor (NP) survival and migration for the treatment of neurodegenerative diseases and brain injuries. The project investigates the potential of adult central nervous system (CNS) endothelial cells to express developmental...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $631,340.00 to Ann & Robert H Lurie Children's Hospital of Chicago to investigate the contribution of HSV-2 ICP34.5 variation to neurovirulence during neonatal infection. The research aims to determine how naturally-occurring genomic variations in the HSV-2 G34.5 gene...