This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $543,337 to Vanderbilt University to support research on long-distance regressive signaling processes that underlie the sculpting of the nervous system during development. The research aims to characterize the features of the p75 neurotrophin receptor (p75NTR) in regressive signaling events, such as apoptosis, axon degeneration, and synapse restriction, as well as investigate how progressive signaling from NGF-TrkA influences these processes. Additionally, the study will examine the role of p75NTR palmitoylation in regressive signaling and assess its physiological effects on developmental events in vivo. The overarching goal is to advance the understanding of long-distance regressive signaling and its regulation in nervous system development, which holds significance for neurodevelopmental and neurodegenerative disorders.
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