The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $458,189 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of Texas Medical Branch at Galveston (UTMB) to conduct research on how membrane-remodeling factors regulate oligodendrocyte form and function in central nervous system (CNS) myelination. The research aims to: 1) identify membrane-remodeling factors expressed in oligodendroglia and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $1,500,600.00 to the Rector & Visitors of the University of Virginia (UVA) to investigate the role of specific genes, including TMEM125B and JAMs 2 & 3, in regulating central nervous system (CNS) myelination. The research aims to: 1) determine the function...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research focused on understanding the molecular mechanisms of oligodendrocyte myelination and remyelination. The $614,009 award to Childrens Hospital Medical Center in Cincinnati, Ohio aims to identify critical factors that promote myelin production from...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $352,073 to support research on targeting the ABCA1 cholesterol transporter to correct myelin formation issues in hereditary neuropathies. The research, led by the University of Nevada, Reno, aims to advance the development of a novel drug candidate identified by collaborator...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,949,990 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute. The grant, spanning 5 years from August 2024 to June 2029, supports research evaluating the therapeutic potential of hypoxia mimetics in treating inflammatory demyelinating diseases like multiple sclerosis. Specifically, the grant funds efforts to:...
This federal Project Grant award, valued at $599,204.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the cellular mechanisms that drive learning-induced myelin remodeling and its role in motor learning. The key objectives are to: (1) determine whether calcium signaling is required for myelin sheath shortening...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $440,275 to The Research Foundation For The State University Of New York to conduct systematic discovery of upstream regulators of the OLIG2 gene, which is a master regulator of oligodendrocyte lineage cells critical for central nervous system myelination. The award period is...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $484,125 five-year Project Grant (R01NS140248) to Trustees of Dartmouth College under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The funding will support research to determine how disruptions and alterations in mitochondrial dynamics, including fission, fusion, motility, generation, and degradation, impact oligodendrocyte precursor cell fate and...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $235,500.00 to Rutgers, The State University to conduct research on the role of the choline transporter CTL1 in oligodendrocytes and its implications for myelin formation and maintenance. The research aims to elucidate how oligodendrocytes acquire choline, a critical...
This $210,600 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to investigate how Wnt signaling mediates the formation of repair cells from Schwann cells in the peripheral nervous system. The primary goals are to 1) provide functional tests of the role of Wnt receptors and ligands in controlling repair cell...