This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA Program 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $576,142.00 to Oregon Health & Science University (OHSU) to conduct research on the molecular and genetic regulation of myelin capacity in the central nervous system (CNS). The key objectives are to: 1) Define the cellular mechanisms by which the FBXW7 protein regulates oligodendrocyte development, myelination, and myelin homeostasis; 2) Determine the role of FBXW7 in remyelination; and 3) Identify the FBXW7 target proteins in oligodendrocytes that promote myelination, with a focus on FBXW7's regulation of the MYRF protein. This research, conducted from June 2025 through March 2030, aims to enhance the understanding of oligodendrocyte biology and lay the foundation for future therapies to stimulate myelin repair in neurological disorders.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $576.1k | 6/19/25 |