Project Grant R21MH144687
Award Date 8/1/26
Completion Date 7/31/28
Dollars Obligated $451K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
Similar Awards
- The National Institute of Mental Health awarded The Regents of the University of California, San Francisco $832,307 on April 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research into the genetic control of basal telencephalic development and the transcriptional and epigenetic mechanisms governing forebrain GABAergic neuron differentiation. The research addresses dysregulation of basal ganglia and cortical development as a central factor in epilepsy,...
- The National Institute of Mental Health awarded the University of Wisconsin - Madison $388,750 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop machine learning methods and tools for comparative single-nucleus multiomics analysis between human pluripotent stem cell organoids and developing brains. The award funds development of a machine learning method, referred to as Brain Organoid Manifold Alignment for multiomics data (an extension of the existing...
- The National Institute of Mental Health awarded Emory University $780,866 on July 2, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on human induced pluripotent stem cell (hiPSC) and progenitor heterogeneity as predictors of variability in three-dimensional human neural differentiation. The award funds the Brain Organoid Hub at Emory University to investigate why region-specific brain organoids derived from hiPSCs exhibit high variability in...
- The National Institute of Mental Health, National Institutes of Health awarded The Regents of the University of California, San Francisco $117,747 on June 1, 2026 under the Mental Health Research Grants program (CFDA 93.242) for functional characterization of schizophrenia-related risk genes and variants in neurogenesis using cerebral organoids. The project investigates how schizophrenia-associated genetic variants disrupt neurogenesis, the developmental process by which neurons form in the...
- The National Institute of Mental Health awarded The Regents of the University of California, San Francisco $800,384 on March 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct molecular and functional dissection of prefrontal-hippocampal long-range inhibition. The project investigates a novel long-range GABAergic pathway from prefrontal cortex to hippocampus that mediates top-down control of hippocampal function. The research will elucidate mechanisms through...
- The National Institute of Mental Health awarded the Regents of the University of Michigan $429,000 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of gene dosage in synaptic development using human cerebral organoids. The recipient will develop induced pluripotent stem cell-derived cerebral organoids engineered with deletion or duplication of the genomic region surrounding retinoic acid induced 1 (RAI1) to examine how RAI1 dosage...
- The National Institute of Mental Health awarded $437,870 to the University of California, Davis on July 1, 2026 under the Mental Health Research Grants program (CFDA 93.242) to investigate mechanisms of satellite oligodendroglia-neuron interaction during brain maturation. The project, titled "Mechanisms of Satellite Oligodendroglia-Neuron Interaction in Brain Maturation," addresses disruptions in postnatal brain maturation implicated in neurological disorders including autism, cerebral...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $426,991 under the Mental Health Research Grants program (CFDA 93.242) on August 3, 2026, to support research decoding medial prefrontal cortex (MPFC) plasticity across developmental life stages. The recipient is investigating critical periods of synaptic plasticity in the MPFC using high-throughput assays measuring long-term potentiation in mouse brain slices via multielectrode recording arrays. Aim 1 maps...
- The National Institute of Mental Health awarded The Regents of the University of California, San Francisco $117,747 on May 22, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on neural computations underlying flexible control of behavioral strategies and problem-solving. The award funds a K99 Pathway to Independence Award project combining large-scale electrophysiology with closed-loop optogenetics in freely behaving rats performing strategy-switching...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...