Project Grant R01MH139197
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded $818,253 to The Regents of the University of California, San Francisco under the Mental Health Research Grants program (CFDA 93.242) beginning July 1, 2025, and extending through April 30, 2030. This Project Grant supports a five-year research investigation examining neuromodulatory system abnormalities in late-life depression (LLD), with specific focus on the associations between structural and functional brain...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a Project Grant of $121,933.00 to the University of California, San Diego under the Mental Health Research Grants program (CFDA 93.242) for the period of June 1, 2025 through May 31, 2027. This research project will deliver scientific investigation into compartment-specific synaptic organization and plasticity in layer 2/3 pyramidal neurons during learning in behaving animals. The research employs cutting-edge...
- Federal Project Grant Award Summary The University of California, San Diego received a $415,664 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded on March 15, 2026, with a completion date of December 31, 2030. This award supports a research project investigating the dissociable roles of distinct orbitostriatal circuits in value-based decision-making. The research employs advanced neuroscientific...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded University of California, Berkeley a Project Grant totaling $1,170,843 under the Mental Health Research Grants program (CFDA 93.242), effective April 1, 2026 through February 28, 2029. The award supports research on optical control of deep synaptic signaling, advancing fundamental neuroscience understanding of synaptic plasticity and memory storage mechanisms in the mammalian brain. The project delivers innovative...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a Project Grant of $200,376.00 under the Mental Health Research Grants program (CFDA 93.242) to The Regents of the University of California, San Francisco for research activities spanning April 1, 2026, through March 31, 2031. The grant funds a longitudinal research investigation examining the mechanisms through which prenatal maternal inflammation (PMI) and parenting behaviors influence child mental health...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), awarded UCLA a project grant of $125,556 (obligated October 25, 2025) to investigate the neuronal correlates of avoidance and pursuit during human ambulatory navigation. This three-year research initiative, scheduled for completion by November 30, 2028, will examine how the medial temporal lobe—including the hippocampus, amygdala, nucleus accumbens, and...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Virginia a $768,909 Project Grant under the Mental Health Research Grants program (CFDA 93.242) effective May 1, 2025, through January 31, 2030. This research initiative, titled "Synchronous Network Activity in the Maturing Prefrontal Cortex: Mechanistic Impact of Birth Timing and Serotonin," investigates how premature birth affects brain development and cognitive function. The...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Regents of the University of California, San Francisco a Project Grant of $458,177 under the Mental Health Research Grants program (CFDA 93.242) for the period June 9, 2025 through June 8, 2027. The research project, titled "Leveraging Population Level Data to Inform Prevention and Treatment of Adolescent Depression Following Social Adversities," addresses the significant gap between current...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a Project Grant totaling $196,597.00 under the Mental Health Research Grants program (CFDA 93.242) to The Regents of the University of California, San Francisco, effective July 1, 2025, through June 30, 2029. This four-year research initiative investigates the neurobiological mechanisms underlying autism spectrum disorder (ASD) phenotypes, specifically examining how a high-risk ASD gene mutation produces...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $238,356 to The Regents of the University of California, San Francisco under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on August 15, 2025. This Project Grant supports a five-year research initiative (through July 31, 2030) investigating the amygdala-nucleus reticularis thalami (NRT) neural pathway and its influence on brain circuit...
The National Institute of Mental Health (NIMH) awarded The Regents of the University of California, San Francisco $800,384 under the Mental Health Research Grants program (CFDA 93.242) on March 10, 2026, for a project titled "Molecular and Functional Dissection of Prefrontal-Hippocampal Long-Range Inhibition." This Project Grant supports basic neuroscience research investigating the mechanisms through which the prefrontal cortex exerts top-down control over hippocampal function through a novel long-range GABAergic (gamma-aminobutyric acid-based inhibitory) pathway. The research will elucidate how prefrontal projections regulate hippocampal information processing and cognitive functions including object exploration and memory-related processes. The funded research will deliver scientific findings regarding the heterogeneity of prefrontal GABAergic neurons projecting to the hippocampus and the detailed circuit mechanisms through which these long-range projections alter downstream hippocampal computation. Through molecular and functional dissection approaches, the project will test the hypothesis that long-range GABAergic projections control the hippocampus by targeting disinhibitory microcircuits, thereby regulating how competing input regions recruit feedforward inhibition and enable switching between different information processing modes. The five-year project, with completion targeted for December 31, 2030, is being conducted at UCSF's San Francisco facility and will advance fundamental understanding of prefrontal-hippocampal neural circuits relevant to cognitive and emotional processes.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $800.4k | 3/10/26 |