Project Grant R21MH143121
- The National Institute of Mental Health awarded The Leland Stanford Junior University $734,707 on August 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the coordinated maturation of neurons and synapses in the adolescent human neocortex. The research develops a pipeline to retrieve and analyze tissue specimens resected during pediatric neurosurgical procedures for epilepsy, vascular malformations, or brain tumors. The study examines whether postnatal...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $620,848 on August 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a novel neural dynamic model characterizing volatility and rigidity of brain state dynamics in relation to youth externalizing behaviors. The research leverages the large-scale, longitudinal Adolescent Brain Cognitive Development (ABCD) dataset and employs single-trial and state-space models to...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $128,206 on September 1, 2026, under Mental Health Research Grants (CFDA 93.242, Assistance Type: Project Grant) to develop and apply next-generation imaging and perturbation technologies for mapping and manipulating cortex-wide networks during social behavior in autism spectrum disorder models. The funded research addresses cortical network dysregulation in autism by combining ultrasensitive dual-color...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $192,192 on April 15, 2026, to develop an artificial intelligence foundation model for functional neuroimaging that predicts treatment response, stratifies patients, and identifies biotypes in major depressive disorder under CFDA 93.242 (Mental Health Research Grants). The award funds three specific aims. Aim 1 applies pooled functional MRI data from individuals with major depressive disorder to fine-tune a...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $977,740 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct research examining sleep as a predictor of depression onset in adolescence. The research applies a deep-learning framework to two large public longitudinal datasets—the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA; N=624) and the Adolescent Brain Cognitive Development Cohort...
- The National Institute of Mental Health awarded $452,386 to President and Fellows of Harvard College on September 1, 2026, to study the plasticity of synaptic cotransmission in the mouse lateral habenula under the Mental Health Research Grants program (CFDA 93.242). The research investigates how changes in the valence of learned associations induce synaptic plasticity in the lateral habenula—a brain structure implicated in mood disorders—and subsequently alter downstream dopamine signaling....
- The National Institute of Mental Health awarded California Institute of Technology $1,417,650 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop instrumentation for synchronized multimodal recording and analysis of human behavior and neural activity during complex, unstructured tasks. The project develops a system to acquire and synchronize behavioral data streams including head-mounted eye tracking to monitor gaze position, egocentric and...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $721,645 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to identify multimodal prognostic markers predictive of psychosis transition in youths at clinical high risk using artificial intelligence and large-scale multimodal data from clinical, cognitive, and neurobiological sources. The recipient will develop and validate an AI-based computational framework combining explainable...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...
- The National Institute of Mental Health awarded The Regents of the University of California, San Francisco $117,747 on May 22, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on neural computations underlying flexible control of behavioral strategies and problem-solving. The award funds a K99 Pathway to Independence Award project combining large-scale electrophysiology with closed-loop optogenetics in freely behaving rats performing strategy-switching...
The National Institute of Mental Health awarded The Leland Stanford Junior University $426,991 under the Mental Health Research Grants program (CFDA 93.242) on August 3, 2026, to support research decoding medial prefrontal cortex (MPFC) plasticity across developmental life stages. The recipient is investigating critical periods of synaptic plasticity in the MPFC using high-throughput assays measuring long-term potentiation in mouse brain slices via multielectrode recording arrays. Aim 1 maps MPFC developmental plasticity by measuring long-term potentiation and perineuronal net expression across developmental stages; Aim 2 manipulates perineuronal nets and neural activity through pharmacological and optogenetic interventions (DREADDs) to test whether adult critical periods can be reopened. Work is performed in Palo Alto, California, with a period of performance through August 2, 2028. The award is structured as a Project Grant, the standard assistance type under the Mental Health Research Grants program, which supports basic and clinical research to advance the understanding and treatment of mental illness.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.0k | 8/5/26 |