Project Grant R21MH144311
- The National Institute of Mental Health awarded the Regents of the University of Michigan $761,595 on June 1, 2026, under Mental Health Research Grants (CFDA 93.242) to evaluate efficiency of evidence accumulation as a neurodevelopmental mechanism of transdiagnostic risk for psychopathology using computational modeling approaches. The research investigates how neurocognitive abilities supporting adaptive decision-making and self-regulation—inhibition, working memory, and related...
- The National Institute of Neurological Disorders and Stroke awarded the Regents of the University of Michigan $146,630 on June 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This Project Grant (R03NS148802) funds research to identify the histone and non-histone substrates of the neuronal LSD1-PHF21A chromatin regulator complex, with the goal of clarifying neuron-specific chromatin regulation mechanisms and their role in...
- The National Institute of Mental Health awarded $451,000 to The Regents of the University of California, San Francisco on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) for a Project Grant (R21MH144687) running through July 31, 2028. The award funds research to develop synthetic organizer cells that control multi-axis patterning in three-dimensional brain organoids. Current organoid generation methods lack reproducibility in cell-type patterning and spatial...
- The National Institute of Mental Health awarded $442,750 to the University of California, Davis on July 1, 2026 under the Mental Health Research Grants program (CFDA 93.242) to investigate synaptic plasticity and signaling mechanisms in 22Q11.2 deletion syndrome model mice. The research addresses learning and memory deficits in 22Q11.2 deletion syndrome, the most common chromosomal microdeletion in humans (incidence approximately 1 in 4,000 live births), which presents broad symptoms including...
- The National Institute of Mental Health awarded University of California, Los Angeles $764,785 under the Mental Health Research Grants program (CFDA 93.242) on July 16, 2026, to investigate context-dependent disease mechanisms in neurodevelopmental disorders, specifically the 16p11.2 chromosomal deletion (16PDEL) implicated in autism, intellectual disability, and ADHD. The project will use a proprietary in vitro human stem cell platform called the Cell Village to conduct high-throughput...
- The National Institute of Mental Health awarded Michigan State University $416,859 on March 3, 2026, under the Mental Health Research Grants program (CFDA 93.242) to probe nucleolus function in a mouse model of Fragile X Syndrome. The research aims to explore nucleolar hyper-function as a novel aspect of FXS pathology. The investigator proposes that this hyper-function drives aberrant ribosome biogenesis, thereby increasing cellular translation capacity and explaining the elevated global protein...
- The National Institute of Mental Health awarded the University of Wisconsin - Madison $388,750 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop machine learning methods and tools for comparative single-nucleus multiomics analysis between human pluripotent stem cell organoids and developing brains. The award funds development of a machine learning method, referred to as Brain Organoid Manifold Alignment for multiomics data (an extension of the existing...
- The National Institute of Mental Health awarded Michigan State University (doing business as Henry Ford Health+Michigan State University Health Sciences) $431,750 on March 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop transgenic tools for experimental access to semilunar granule cells in the mouse dentate gyrus and to test whether these cells constrain granule cell activity in vivo. The project addresses a gap in neuroscience methodology: while genetic...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $734,707 on August 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the coordinated maturation of neurons and synapses in the adolescent human neocortex. The research develops a pipeline to retrieve and analyze tissue specimens resected during pediatric neurosurgical procedures for epilepsy, vascular malformations, or brain tumors. The study examines whether postnatal...
- The National Institute of Mental Health awarded Children's Research Institute $654,005 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of paralaminar amygdala neurons from adolescence to adulthood using a mouse model. The recipient will examine how paralaminar nucleus neuronal responses change over the adolescent-to-early-adulthood transition, determine the necessity and sufficiency of these neurons in that transition, and characterize...
The National Institute of Mental Health awarded the Regents of the University of Michigan $429,000 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of gene dosage in synaptic development using human cerebral organoids. The recipient will develop induced pluripotent stem cell-derived cerebral organoids engineered with deletion or duplication of the genomic region surrounding retinoic acid induced 1 (RAI1) to examine how RAI1 dosage regulates the tempo of synapse development. The project tests the hypothesis that RAI1 deletion accelerates synaptic development while duplication slows it, using human models rather than rodent disease models to capture the unique prolongation of human synaptic refinement known as synaptic neoteny. This work addresses Smith-Magenis Syndrome (caused by RAI1 haploinsufficiency) and Potocki-Lupski Syndrome (resulting from RAI1 duplication), neither of which currently has mechanism-based treatment available. Work is performed at the University of Michigan, Ann Arbor, Michigan, with a period of performance from September 1, 2026, through August 31, 2028. The award is a project grant, the assistance type used by NIMH for investigator-initiated research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.0k | 8/25/26 |