Project Grant R21MH144157
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $162,560 on February 4, 2027, under the Mental Health Research Grants program (CFDA 93.242) to define molecular pathways in monoamine circuit development using autism-related syndrome genes in zebrafish. The recipient will conduct behavioral assays, sequencing, and imaging of monoamine circuits and brain-wide activity changes in zebrafish with mutations in genes associated with autism-related...
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $125,169 on July 30, 2026, under the Mental Health Research Grants program (CFDA 93.242, assistance type: Project Grant) to investigate brain metabolic dysfunction as a mechanism underlying autism spectrum disorder. The project uses non-invasive magnetic resonance spectroscopy to measure brain metabolites as markers of metabolic dysfunction in autistic adolescents relative to non-autistic peers,...
- The National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), awarded a $431,750 Project Grant to Rutgers, The State University of New Jersey. The award will fund research into the molecular mechanisms behind the sex-specific deficits observed in neurodevelopmental disorders such as autism spectrum disorder (ASD). The research aims to investigate how hormones and sex-specific signaling interact in the development of behavioral deficits, using...
- The National Institute of Mental Health awarded Cold Spring Harbor Laboratory $528,000 on June 19, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support developmental characterization of synapses between neurons and oligodendrocyte precursor cells. The funded research investigates structural, functional, and molecular properties of neuron-OPC synapses, a class of synaptic connections that remain poorly understood despite evidence that oligodendrocyte precursor cells...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $805,382 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study social perception and cognition in a marmoset model of Phelan-McDermid Syndrome. The award funds research into neural impairments in social perception and cognition caused by SHANK3 gene mutations, with investigation of whether gene therapy can correct those impairments. MIT will implant electrocorticography...
- The National Institute of Mental Health awarded Massachusetts General Hospital $824,728 on March 25, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize intracortical feedforward and feedback sensory processes in autism spectrum disorder. The award funds a multimodal neuroimaging study examining the hypothesis that autism spectrum disorder involves a fundamental imbalance between bottom-up (feedforward) and top-down (feedback) information flow in sensory cortex....
- The National Institute of Mental Health awarded the Research Foundation For Mental Hygiene, Inc. $467,368 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct an exploratory study investigating the relationship between maternal serotonin levels during early pregnancy and offspring neurodevelopment. The recipient, operating through its New York State Psychiatric Institute division in New York, will analyze existing data from an ongoing prospective cohort...
- This federal Project Grant award of $444,125, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research investigating the role of the serotonergic system in social behavior following early life adversity. The research team at George Washington University will utilize electrophysiology, behavioral assays, and fiber photometry to examine how early life stress alters the excitability of serotonergic neurons and...
- This federal Project Grant award of $422,280, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to identify and interrogate novel intracellular proteins that underlie the distinct nanoscopic architecture of the neurexin-1 and neurexin-3 proteins. The research aims to determine how the intrinsically monomeric neurexins are organized into discrete and homogeneous nanoclusters, which is a fundamentally...
- The National Institute of Mental Health awarded the University of Maryland, Baltimore $762,566 under the Mental Health Research Grants program (CFDA 93.242) on April 1, 2026 to conduct comprehensive multi-omic and synaptic imaging studies of the cerebellum in autism spectrum disorders. The project will generate single-nuclei multi-omic profiles of gene expression and chromatin accessibility in approximately 1.5 million cells from 100 autism spectrum disorder cases and 100 controls, utilizing...
The National Institute of Mental Health awarded University of Massachusetts Medical School $460,625 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurexin genes' role in serotonin circuitry and social behavior deficits associated with autism spectrum disorder. The award is a Project Grant (R21MH144157) with performance period through July 31, 2028, and place of performance in Worcester, Massachusetts. The research elucidates molecular mechanisms of serotonin circuit formation and identifies specific serotonergic circuits responsible for social behavior by focusing on neurexin genes as a risk factor for autism spectrum disorder and schizophrenia. The work uses genetically modified mouse models to examine how neurexins, presynaptic cell-adhesion molecules involved in synapse formation, influence serotonin signaling to the interpeduncular nucleus—a brain region implicated in social behavior. Preliminary data demonstrate social behavior deficits in serotonin neuron-specific neurexin triple knockout mice and altered serotonin projections to the interpeduncular nucleus, supporting investigation of this circuit's molecular basis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $460.6k | 8/4/26 |