Project Grant R21MH140036
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $762,566 Project Grant to the University of Maryland, Baltimore effective April 1, 2026, through December 31, 2030, under the Mental Health Research Grants program (CFDA 93.242). The award funds comprehensive multi-omic and synaptic imaging research to quantify cerebellar mechanisms underlying Autism Spectrum Disorders (ASDs). The research will generate single-nuclei multi-omic profiles analyzing gene expression...
- Federal Project Grant Award Summary Baylor College of Medicine received a $701,256 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective June 5, 2026 through March 31, 2031. This award funds basic neuroscience research investigating the mechanisms of protein phosphorylation at the axon initial segment (AIS), a neuronal structure critical to action potential generation and neuronal polarity that is frequently...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $763,894 Project Grant to The Washington University (Office of Sponsored Research Services) effective June 19, 2026, with completion targeted for April 30, 2031, under the Mental Health Research Grants program (CFDA 93.242). This award funds a comprehensive mechanistic investigation of ZNF292, a recently identified neurodevelopmental disorder (NDD) gene associated with autism spectrum disorder (ASD),...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded University of Colorado-Denver $429,000 under the Mental Health Research Grants program (CFDA 93.242) for a two-year exploratory research project spanning June 1, 2025 through May 31, 2027. The project, titled "A Synaptogenic Adhesion Code for Myelin Specificity," investigates the molecular mechanisms underlying myelin formation and white matter abnormalities associated with autism spectrum disorder (ASD)...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded Children's Research Institute a Project Grant of $654,005 under CFDA 93.242 (Mental Health Research Grants) on June 1, 2026, with a completion date of March 31, 2031. This award funds basic neuroscience research investigating the function of the paralaminar nucleus of the amygdala (PL) from adolescence to early adulthood using mouse models. The research seeks to advance understanding of how late-maturing...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a Project Grant of $121,933.00 to the University of California, San Diego under the Mental Health Research Grants program (CFDA 93.242) for the period of June 1, 2025 through May 31, 2027. This research project will deliver scientific investigation into compartment-specific synaptic organization and plasticity in layer 2/3 pyramidal neurons during learning in behaving animals. The research employs cutting-edge...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $534,191 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) on April 1, 2026, through the Mental Health Research Grants program (CFDA 93.242). The award supports research through December 31, 2030, focusing on the development of robust fine-mapping tools and novel statistical methods for genetic discovery in neuropsychiatric traits using deep phenotype data....
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded Scripps Research Institute $878,601 under the Mental Health Research Grants program (CFDA 93.242) on April 1, 2026, for a project titled "Structural Remodeling of Neural Circuits Via Multisynaptic Boutons," running through December 31, 2030. This collaborative research initiative delivers integrated neuroscience research services combining three-dimensional electron microscopy (3D-EM), chemogenetic...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $427,625 Project Grant to the University of Maryland, Baltimore (effective September 11, 2025 through September 10, 2027) under the Mental Health Research Grants program (CFDA 93.242) to fund basic neuroscience research on synaptic transmission mechanisms. The project focuses on identifying and characterizing the molecular organization of docked synaptic vesicles at presynaptic active zones and...
- Federal Grant Award Summary Massachusetts General Hospital's Research Management Division received a $824,728 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) on March 25, 2026, with an ultimate completion date of December 31, 2030. The award funds a multimodal neuroimaging research project investigating intracortical feedforward and feedback sensory processes in Autism Spectrum Disorder (ASD). The research employs...
Cold Spring Harbor Laboratory received a $528,000 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded on June 19, 2026, with completion scheduled for June 18, 2028. The award funds a developmental characterization study of synapses between neurons and oligodendrocyte precursor cells (OPCs), addressing a significant gap in neuroscience understanding that has implications for autism and related neurodevelopmental disorders. This research will systematically characterize neuron-OPC synaptic connections across structural, functional, and molecular levels—an area currently poorly understood despite evidence that OPCs express high levels of neuroligin family synaptic adhesion molecules, which are among the strongest genetic drivers of autism risk. The project aims to identify which specific populations of synapses are affected in autism and elucidate the mechanisms underlying their developmental impairments. By advancing knowledge of neuron-OPC synaptic biology beyond existing neuron-to-neuron synapse research, this work has potential to inform more targeted pharmacological strategies for treating neurodevelopmental conditions. The award supports fundamental biological research aligned with NIMH's mission to transform understanding and treatment of mental illnesses through basic and clinical research, with the research taking place at Cold Spring Harbor Laboratory's facility in Cold Spring Harbor, New York.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $528.0k | 6/23/26 |