Project Grant K99MH144590
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $162,560 on February 4, 2027, under the Mental Health Research Grants program (CFDA 93.242) to define molecular pathways in monoamine circuit development using autism-related syndrome genes in zebrafish. The recipient will conduct behavioral assays, sequencing, and imaging of monoamine circuits and brain-wide activity changes in zebrafish with mutations in genes associated with autism-related...
- The National Institute of Mental Health awarded Massachusetts General Hospital $824,728 on March 25, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize intracortical feedforward and feedback sensory processes in autism spectrum disorder. The award funds a multimodal neuroimaging study examining the hypothesis that autism spectrum disorder involves a fundamental imbalance between bottom-up (feedforward) and top-down (feedback) information flow in sensory cortex....
- The National Institute of Mental Health awarded the University of California, Davis $123,498 under the Mental Health Research Grants program (CFDA 93.242) on June 5, 2026, to support research improving the quality and acceptability of autism services. The award is structured as a K99 (Pathway to Independence) Project Grant, supporting investigation into the safety, validity, and ethics of early intervention approaches for autism in light of concerns raised by the neurodiversity movement and...
- The National Institute of Mental Health awarded University of Massachusetts Medical School $460,625 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurexin genes' role in serotonin circuitry and social behavior deficits associated with autism spectrum disorder. The award is a Project Grant (R21MH144157) with performance period through July 31, 2028, and place of performance in Worcester, Massachusetts. The research elucidates molecular...
- The National Institute of Mental Health awarded the University of Maryland, Baltimore $762,566 under the Mental Health Research Grants program (CFDA 93.242) on April 1, 2026 to conduct comprehensive multi-omic and synaptic imaging studies of the cerebellum in autism spectrum disorders. The project will generate single-nuclei multi-omic profiles of gene expression and chromatin accessibility in approximately 1.5 million cells from 100 autism spectrum disorder cases and 100 controls, utilizing...
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $474,500 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the relationship between puberty, interoceptive neural networks, and anxiety symptoms in adolescents. The research employs functional magnetic resonance imaging to characterize how pubertal changes to cortical body representation in primary somatosensory and insular cortices relate to...
- The National Institute of Mental Health awarded the University of California, Davis $171,018 on September 25, 2025, under the Mental Health Research Grants program (CFDA 93.242) to support a predoctoral fellowship dissertation investigating brain aging in adults with autism spectrum disorder. The fellow will characterize age-related changes in neuroimmune profiles, immune cell phenotypes, and neuronal inflammation throughout adulthood in individuals with autism spectrum disorder. The research...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $128,206 on September 1, 2026, under Mental Health Research Grants (CFDA 93.242, Assistance Type: Project Grant) to develop and apply next-generation imaging and perturbation technologies for mapping and manipulating cortex-wide networks during social behavior in autism spectrum disorder models. The funded research addresses cortical network dysregulation in autism by combining ultrasensitive dual-color...
- The National Institute of Mental Health awarded The Children's Hospital Corporation (Boston Children's Hospital) $990,550 on March 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and test a computer-based cognitive control and metacognition training intervention designed to reduce restricted and repetitive behaviors in school-aged children with autism spectrum disorder. The R61 phase of this R61/R33 phased project grant will randomly assign 95 autistic children...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (Massachusetts General Hospital) $129,330 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on August 6, 2026. The funded research quantifies folate receptor binding potential in the human choroid plexus using MRI-PET imaging. The work addresses a critical gap in understanding cerebral folate transport in autism spectrum disorder,...
The National Institute of Mental Health awarded the University of Massachusetts Medical School $125,169 on July 30, 2026, under the Mental Health Research Grants program (CFDA 93.242, assistance type: Project Grant) to investigate brain metabolic dysfunction as a mechanism underlying autism spectrum disorder. The project uses non-invasive magnetic resonance spectroscopy to measure brain metabolites as markers of metabolic dysfunction in autistic adolescents relative to non-autistic peers, examining three metabolic systems involved in brain development and functioning: the glutamate/gaba-glutamine cycle, energy metabolism, and phospholipid metabolism. The research acquires magnetic resonance imaging measures of functional and structural brain connectivity and tests whether dysfunction in each metabolic system relates to social cognition deficits via altered brain connectivity. Specific Aim 1 examines associations between glutamate/gaba-glutamine cycle dysfunction, functional connectivity, and social cognition in autism. Specific Aim 2 identifies alterations in brain energy metabolism and examines associations between brain energy metabolism, functional connectivity, and social cognition. Specific Aim 3 investigates phospholipid metabolic dysfunction. The award period runs from July 30, 2026, through June 30, 2028, with work performed at the University of Massachusetts Medical School in Worcester, Massachusetts. The K99/R00 award structure supports career transition to independence.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.2k | 7/31/26 |