The National Institute of Mental Health (NIMH) awarded a $422,280 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Colorado-Denver to identify and investigate novel intracellular proteins that contribute to the distinct nanoscopic architecture of the synaptic adhesion molecules neurexin-1 and neurexin-3. The 2-year grant, which runs from April 1, 2025 to March 31, 2027, will employ advanced super-resolution imaging techniques to dissect how the cytoplasmic protein p130CAS regulates the surface expression, nanoscale organization, and synaptic function of neurexin-1. This research aims to provide critical insights into how neurexin nanoclusters are established and how individual neurexins differentially control intracellular signaling at excitatory synapses.
Generated 3/25/25, 6:11 AM