This $188,393 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the Board of Regents of the Nevada System of Higher Education, doing business as the University of Nevada, Las Vegas (UNLV). The goal of this 4-year project is to investigate the contribution of noncoding tandem repeat expansions to the etiology of autism spectrum disorder (ASD). The research aims to:...
This Project Grant award of $714,615 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research by New York University to dissect the mechanisms by which noncoding repeat expansions in the CACNA1C gene contribute to the risk of psychiatric disorders like schizophrenia and bipolar disorder. The key objectives are to: 1) fine map regulatory activity at the CACNA1C repeat using long-read sequencing approaches, 2)...
The National Human Genome Research Institute (NHGRI) awarded a $422,125 Project Grant (CFDA 93.172 - Human Genome Research) to the University of Miami to develop novel analytical tools and resources for the study of tandem repeats (TRs) in the context of the All of Us Research Program (AOURP) data. This project aims to characterize the recently established AOURP long-read sequencing data, which includes over 3.5 billion TR alleles from 1,027 participants. The University of Miami will develop...
This $718,662 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to characterize the genetic regulation of alternative polyadenylation (APA) in the developing human brain and its contribution to neuropsychiatric disorders like autism spectrum disorder (ASD) and schizophrenia (SCZ). The project aims to generate a comprehensive atlas of APA regulation across neurodevelopment, leveraging data from...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $429,000.00 in funding to Thomas Jefferson University to conduct research on cell-type specific analysis of Src kinase-NMDA receptor complexes in schizophrenia. The goal of this 2-year project is to determine how Src kinase-mediated NMDA receptor signaling alterations are distinctly manifested in pyramidal neurons versus interneurons in the...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA Program 93.242 Mental Health Research Grants, will fund a study to evaluate cognitive systems and psychopathology in autistic individuals who carry rare genetic variants associated with both autism spectrum disorder (ASD) and schizophrenia (SCZ). The study, led by The Trustees of Columbia University in the City of New York, will assess 400 participants with ASD, 200 with ASD+SCZ variants and 200 without,...
This Project Grant award from the National Institute of Mental Health (NIMH), under the CFDA 93.242 Mental Health Research Grants program, provides $183,663 in funding to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on the genetic architecture of neuropsychiatric disorders (NPDs) including autism spectrum disorder (ASD), epilepsy, and schizophrenia. The key objectives of this 4-year research project are to: 1) Apply a rare...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $207,170 to President and Fellows of Harvard College, doing business as Harvard Medical School, to conduct research aimed at uncovering the genomic and transcriptomic variation due to mobile elements in the population and in neurological disease. The key objectives of this 3-year project are to: 1) characterize the broader effects of mobile element...
The National Institute of Mental Health (NIMH) awarded a $911,929 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Scripps Research Institute in La Jolla, CA on September 5, 2024. The grant will fund a research project titled "Scalable Functional Analysis of Neuropsychiatric Risk Genes with Spatially Integrated In Vivo Perturb-Seq." The project aims to combine high-content in vivo genetic screening with whole brain cytoarchitecture spatial information to bridge the...
This federal Project Grant award of $503,448.64 from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports research to develop methods for accurately genotyping short tandem repeat (STR) expansions across sequencing technologies. The award aims to produce a publicly available STR variation database, stratified by ancestry, to enable prioritization of candidate pathogenic STR expansions. It will also develop a computational method to genotype STRs from...