The National Institute of Mental Health (NIMH) awarded a $911,929 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Scripps Research Institute in La Jolla, CA on September 5, 2024. The grant will fund a research project titled "Scalable Functional Analysis of Neuropsychiatric Risk Genes with Spatially Integrated In Vivo Perturb-Seq." The project aims to combine high-content in vivo genetic screening with whole brain cytoarchitecture spatial information to bridge the...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to advance the understanding of the shared neural foundations and genetic pathways underlying psychiatric disorders. The $702,928 award, granted on January 21, 2025, will enable a 5-year research project at the University of Pennsylvania to: Integrate common and rare genetic variations to understand the co-architecture of psychiatric disorders and...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA Program 93.242 Mental Health Research Grants, will fund a study to evaluate cognitive systems and psychopathology in autistic individuals who carry rare genetic variants associated with both autism spectrum disorder (ASD) and schizophrenia (SCZ). The study, led by The Trustees of Columbia University in the City of New York, will assess 400 participants with ASD, 200 with ASD+SCZ variants and 200 without,...
This federal Project Grant award of $800,485 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the role of human-specific 3D genome conformation in brain development and disease. The primary awardee, Oregon Health & Science University (OHSU), will analyze cortical neuroprogenitor cells and glutamatergic neurons from human, chimpanzee, orangutan, and rhesus macaque to identify human-specific...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $165,796 to the University of California, Los Angeles (UCLA) to conduct research on the impact of autism spectrum disorder (ASD) genetic risk on microglial function and neuronal-microglial interactions. The research aims to leverage human stem cell culture and 3D human cortical spheroid models to assess how ASD genetic risk factors, such as...
This Project Grant award from the National Institute of Mental Health (NIMH), under the CFDA 93.242 Mental Health Research Grants program, provides $183,663 in funding to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on the genetic architecture of neuropsychiatric disorders (NPDs) including autism spectrum disorder (ASD), epilepsy, and schizophrenia. The key objectives of this 4-year research project are to: 1) Apply a rare...
This Project Grant award of $714,615 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research by New York University to dissect the mechanisms by which noncoding repeat expansions in the CACNA1C gene contribute to the risk of psychiatric disorders like schizophrenia and bipolar disorder. The key objectives are to: 1) fine map regulatory activity at the CACNA1C repeat using long-read sequencing approaches, 2)...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $3,498,931.00 to Pennsylvania State University and its sub-awardees, Jackson Laboratory and New York University, to conduct a comprehensive investigation of the impact of loss of 100 neurodevelopmental and psychiatric disorder (NPD) genes in mice. The project, titled "Cross Scale Interrogation of NPD Genes (SING) in Mice," aims to examine...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA Program 93.242 - Mental Health Research Grants, will fund a research study at the University of Alabama at Birmingham (UAB) to characterize a genetic mouse model and delineate its function in the brain. The $742,484 award, with a period of performance from January 13, 2025 to October 31, 2029, will support comprehensive experiments to identify novel downstream targets, elucidate behavioral outcome...
This $147,656 Project Grant, awarded on June 16, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Duke University to investigate the role of human-specific non-coding genomic sequences in regulating RNA splicing during cortical development and their potential link to neurological diseases like autism. The funded project aims to: 1) Test the...