Project Grant R00HG012796

Award Date 8/7/24
Completion Date 5/31/27
Dollars Obligated $503K
Federal Grant Program
93.172
Assistance Type
Project Grant
Place of Performance
Aurora, CO 80045, USA
Similar Awards
This $400,000 Project Grant award from the National Human Genome Research Institute (NHGRI) under CFDA 93.172 "Human Genome Research" will support a research program at Brigham & Women's Hospital to develop advanced computational methods for accurately identifying and genotyping structural variants within large genetic biobank datasets. The key objectives of the work are to: 1) create haplotype-informed algorithms to improve detection sensitivity and genotyping accuracy for...
The federal Project Grant award number R00HG012797, totaling $501,191.23, was provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172). The award supports research to develop novel computational methods and integrative models for analyzing single-cell 3D genomics and epigenomic data. Key goals include: Creating a single-cell gene-body associating domain (scGAD) scoring system to explore 3D chromatin architecture in the context of...
The National Human Genome Research Institute (NHGRI) awarded a $422,125 Project Grant (CFDA 93.172 - Human Genome Research) to the University of Miami to develop novel analytical tools and resources for the study of tandem repeats (TRs) in the context of the All of Us Research Program (AOURP) data. This project aims to characterize the recently established AOURP long-read sequencing data, which includes over 3.5 billion TR alleles from 1,027 participants. The University of Miami will develop...
This Project Grant award, valued at $491,366, was issued by the National Human Genome Research Institute (NHGRI) under the Human Genome Research federal grant program (CFDA 93.172). The award is focused on developing new algorithms to robustly map disease-associated genetic variants to critical target genes, particularly in underrepresented populations. Key objectives include: Improving the ability to identify disease-critical genes in non-European populations where data is limited. Developing...
The National Human Genome Research Institute (NHGRI) awarded a $457,920 Project Grant (CFDA #93.172 - Human Genome Research) to The Broad Institute, Inc. to develop a deep reinforcement learning framework for haplotype assembly. Haplotype assembly is critical for understanding human population genetics and disease, as it reconstructs the combination of alleles on maternally and paternally inherited chromosome copies. The Broad Institute, a renowned biomedical and genomic research organization,...
The National Human Genome Research Institute (NHGRI) awarded a $435,406 Project Grant (CFDA 93.172 - Human Genome Research) to the University of Colorado-Denver to explore new strategies for inferring protein-level changes from mRNA abundance measurements. The 2-year project aims to develop conceptual embeddings of proteins that capture information on protein-protein interaction networks and protein sequence, domain, and structure. These embeddings will be evaluated for their utility in...
This federal Project Grant award of $126,830 from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports research to develop a somatic mutation-resolved lineage tracing system. The project aims to reconstruct single-cell genealogical trees and detect associated somatic mutations and epigenetic alterations. This will enable investigations into the impact of genomic modifications on the evolutionary dynamics of hematopoietic stem cells, including during...
The National Human Genome Research Institute (NHGRI) awarded a $1,033,069.24 Project Grant (CFDA 93.172 - Human Genome Research) to The Johns Hopkins University to develop novel statistical methods for data integration across disparate datasets in genetic and epidemiologic studies. The project aims to: Create a framework for building generalized linear models using detailed covariate data from a main study while incorporating summary statistics from an external study, with applications to...
The National Human Genome Research Institute (NHGRI) awarded a $486,000 Project Grant (CFDA 93.172 - Human Genome Research) to The Johns Hopkins University to develop a Genomic Medicine Master of Science (M.S.) degree program. The program will provide advanced training to prepare health professionals and trainees with the knowledge and skills required to manipulate, annotate, and interpret human genome data, as well as a foundation for pursuing genomics research. The project leverages the...
The National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), awarded a $1,801,654.98 Project Grant to the University of California, Berkeley on September 10, 2024. The grant aims to develop scalable computational methods and tools for genealogical inference across multiple timescales, from species-level to single-cell genomics. Key objectives include: 1) Accelerating maximum likelihood estimation for models of molecular evolution, 2) Improving...

The federal Project Grant award R00HG012796, totaling $503,448.64, was provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172). The award supports research to develop computational methods for accurately genotyping short tandem repeat (STR) expansions from long-read sequencing data, and to create a publicly available population-scale database of STR variation across diverse ancestries. This research aims to improve genetic diagnosis of STR-associated rare diseases and enable the discovery of new disease-associated STR loci. The project will analyze patient cohorts from organizations including the University of Washington, Harry Perkins Institute, and Children's Mercy Hospital. The award was granted to the University of Colorado-Denver, a prominent public research university, and runs from August 2024 through May 2027.

Generated 8/5/25, 5:42 AM