Project Grant K23MH132874

Award Date 8/19/24
Completion Date 7/31/29
Dollars Obligated $389K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
New York, NY 10032, USA
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The key products and services to be delivered under this award include:

  • Remote assessment of cognition and psychopathology in 400 participants with ASD, 200 of whom carry ASD+SCZ genetic variants and 200 without, at two timepoints
  • Multi-level analysis of the cognitive and psychiatric characteristics of the ASD+SCZ variant subgroup, including task paradigms, self-report, and parent-report measures
  • Examination of how common genetic variation and the type of rare variant moderate the cognitive and psychopathological profiles in the ASD+SCZ variant subgroup
  • Longitudinal assessment of how these characteristics change over time

This research aims to identify a distinct "schizophrenia-like" subgroup within the ASD population based on genetic, cognitive, and psychiatric factors, which could open new opportunities for targeted interventions and improved diagnostic tools across the ASD-schizophrenia spectrum.

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