This $124,488 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research to map cell type-specific isoform diversity in the human brain and dissect the mechanisms of alternative splicing in autism spectrum disorder (ASD). The project, led by Michael Margolis at the University of California, Los Angeles (UCLA), will leverage long-read sequencing technologies to fully characterize the brain's...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is focused on identifying and characterizing moderate effect size (MES) risk genes that contribute to Autism Spectrum Disorder (ASD) liability and presentation. The $844,917 award, which runs from July 1, 2025 to April 30, 2030, aims to pursue four specific objectives: Identify and characterize MES risk genes using rare variation stratified by common...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $237,750 to the University of California, Merced to study the role of the BAF chromatin remodeling complex in experience-induced neuronal gene transcription and synapse maturation, with implications for autism spectrum disorders (ASD). The 2-year project aims to elucidate the functions of the SMARCC2 subunit of the BAF complex in regulating...
The National Institute of Mental Health (NIMH) awarded a $439,804 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Creighton University. The grant supports a 5-year research project (11/15/2024 - 10/31/2029) to investigate the role of the lysine methyltransferase 5B (KMT5B) gene in regulating the expression of insulin-like growth factors (IGF1 and IGF2) and their impact on brain development and autism spectrum disorder. The research aims to specify KMT5B's role in...
This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will fund a $196,597 research project to investigate the information processing changes underlying a high-risk autism spectrum disorder (ASD) gene in rats. The project aims to determine the changes to the hippocampus and its communication with other brain regions in the context of this ASD gene, using advanced techniques such as automated...
The Scripps Research Institute was awarded a $4.6 million project grant from the National Institute of Mental Health to develop novel tools for molecular profiling of brain cell types. The grant is part of NIMH's Mental Health Research Grants program (CFDA 93.242), which supports basic and clinical research to transform the understanding and treatment of mental illnesses. Under the award, Scripps will expand its RIBO-STAMP technology to enable comprehensive measurement of translational...
This $718,662 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to characterize the genetic regulation of alternative polyadenylation (APA) in the developing human brain and its contribution to neuropsychiatric disorders like autism spectrum disorder (ASD) and schizophrenia (SCZ). The project aims to generate a comprehensive atlas of APA regulation across neurodevelopment, leveraging data from...
This Project Grant award from the National Institute of Mental Health (NIMH), under the CFDA 93.242 Mental Health Research Grants program, provides $183,663 in funding to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on the genetic architecture of neuropsychiatric disorders (NPDs) including autism spectrum disorder (ASD), epilepsy, and schizophrenia. The key objectives of this 4-year research project are to: 1) Apply a rare...
The National Institute of Mental Health (NIMH) awarded a $2,247,313 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Brown University. The 5-year grant, awarded on September 1, 2024, will support research to define defective neurodevelopmental mechanisms caused by 17q12 copy number variants (CNVs), particularly 17q12 deletions, which are a high-risk factor for autism and related neurodevelopmental disorders. The research will utilize unique experimental resources...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $165,796 to the University of California, Los Angeles (UCLA) to conduct research on the impact of autism spectrum disorder (ASD) genetic risk on microglia-neuronal interactions. The research aims to leverage human stem cell culture and 3D human cortical spheroid models to assess how ASD genetic risk factors, including mutations in the CHD8 and...