Project Grant R16GM154702

Award Date 8/15/24
Completion Date 6/30/28
Dollars Obligated $188K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Las Vegas, NV 89154, USA
Similar Awards
The National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 (Biomedical Research and Research Training), has awarded a $187,772 project grant to the California State University Long Beach Research Foundation. The grant will fund a study to "Characterize Patterns of Multidimensional Caregiver Engagement by Ethnicity, Acculturation, and Socioeconomic Status, and Identify Barriers and Facilitators to Engagement in ASD Early Intervention Services for Latino...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS, CFDA 93.859 Biomedical Research and Research Training) provides $617,704 to the Pacific Northwest Research Institute to investigate the role of highly similar intrachromosomal repeats in the formation of structural variations and their impact on gene expression and disease phenotypes. The research aims to: 1) identify nonrecurrent copy number variants (CNVs) in disease cohorts and characterize the genomic...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 Mental Health Research Grants provides $464,750 to the Icahn School of Medicine at Mount Sinai to conduct an investigation of tandem repeat variation in schizophrenia. The research leverages recent advancements in algorithms for high-throughput tandem repeat genotyping, which will be applied to large, well-powered schizophrenia cohorts with whole genome sequencing data. The goal is to identify...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to elucidate the molecular mechanisms underlying the genetic disorder myotonic dystrophy type 2. The $434,750 award to the California State University San Marcos Corp will fund a project to investigate DNA repeat instability, chromosomal fragility, and gene expression changes associated with the long CCTG repeats that cause...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $714,615 to New York University School of Medicine to conduct research on the dissection of noncoding repeats in psychiatric genetics using synthetic regulatory genomics. The key products and services to be delivered under this 4-year award include: Detailed analysis of long-read sequencing data to decode the complex structure of the CACNA1C...
The National Institute of Mental Health (NIMH) awarded a Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Scripps Research Institute in La Jolla, CA on September 5, 2024. The $911,929 grant will fund a 5-year research project to combine in vivo genetic screening with spatial mapping of brain cell types to study the mechanisms by which genetic variants associated with autism spectrum disorder (ASD) and neurodevelopmental delay lead to these conditions. The project will adapt...
This $272,125 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate the feasibility of genetically targeted therapies for autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDDs) caused by mutations in epigenetic "writer" enzymes. The principal investigator at The Washington University in St....
This $194,940 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a four-year research program to study the role of somatic (post-zygotic) variants in autism spectrum disorder (ASD). The principal investigator, Dr. Mo, will develop expertise in human genetics, next-generation sequencing data analysis, and interpretation of somatic variants in non-neoplastic tissue. The research aims to: 1) Examine the...
This $900,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project led by North Carolina State University to unravel the mechanisms behind the workings of the DNA mismatch repair systems. The research aims to elucidate the role of atypical nucleic acid structures, such as three-way junctions and R-loops, in driving the expansion of simple sequence repeats (SSRs) within the genome, which is a...
This $253,500 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will support research to resolve the relationship between mitochondrial dysfunction and the impact of non-syndromic autism spectrum disorder (ASD)-related risk genes on neuronal structure and function. The award recipient, the Icahn School of Medicine at Mount Sinai, will establish "two-hit" human induced...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to investigate the contribution of noncoding tandem repeat expansions to the etiology of Autism Spectrum Disorder (ASD). The $188,393 award, granted to the University of Nevada, Las Vegas, will fund a 4-year research project to: 1) identify high-confidence ASD-risk genes with tandem repeat expansions, 2) select tandem repeat expansions based on their potential to disrupt ASD-risk gene transcript processing, and 3) test the hypothesis that intronic tandem repeat expansions alter specific regulatory steps during ASD-risk gene RNA processing. The project seeks to provide a new approach to identify ASD-risk genes from underpowered studies, develop criteria to estimate the propensity of tandem repeat expansions to perturb ASD-risk gene expression, and bridge the gap between genomic findings and their mechanistic basis in ASD. The award also aims to provide research opportunities for underrepresented students and strengthen the recipient's research environment.

Generated 5/13/25, 4:27 AM