Project Grant R21HG013397

Award Date 9/15/23
Completion Date 8/31/25
Dollars Obligated $422K
Federal Grant Program
93.172
Assistance Type
Project Grant
Place of Performance
Florida, USA
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This project aims to characterize the recently established AOURP long-read sequencing data, which includes over 3.5 billion TR alleles from 1,027 participants. The University of Miami will develop machine learning-based tools, normative databases, and analytical workflows to uncover patterns of TR length, motif, and flanking variation across this multi-ancestral dataset. Additionally, the university will analyze TR content in the larger AOURP cohort of over 250,000 Illumina short-read whole genomes. The products of this work will be made available to all AOURP Researcher Workbench users to accelerate the study of TRs and their role in health and disease.

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