Project Grant R43HG013628

Award Date 9/19/24
Completion Date 8/31/25
Dollars Obligated $399K
Federal Grant Program
93.172
Assistance Type
Project Grant
Place of Performance
Hialeah, FL 33010, USA
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This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) is focused on developing and applying machine learning-based approaches to estimate disease risk in diverse and admixed populations. The $399,156 award to Galatea Bio Inc., a minority-owned small disadvantaged business located in Miami Lakes, FL, will support the following key objectives over the project period from September 2024 to August 2025:

  1. Evaluating the performance of existing polygenic risk score (PRS) models for disease risk prediction in individuals of European ancestry using public and proprietary data.
  2. Generating an improved ancestry reference panel with deeper representation of Indigenous American groups.
  3. Developing novel machine learning-based PRS models applicable to individuals with diverse and admixed genetic ancestry.
  4. Implementing a combined ancestry estimation and PRS application for commercial availability through cloud-based platforms.

The goal is to ensure the benefits of improved disease risk prediction through genetic analysis are accessible to all individuals, regardless of their ancestral background.

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