Multi-omics study of ancestry enriched associations in hispanics/latinos
Active Project Grant Awarded Last action
- Award ID
- R01HG013163
- Recipient
-
University Of North Carolina At Chapel Hill UEI D3LHU66KBLD5 Part of University Of North Carolina System Office
- Awarding agency
-
National Human Genome Research Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,697,355
Award facts
- Assistance listing
- 93.172 Human Genome Research
- Completion date 58% complete
- Place of performance
- Chapel Hill, NC 27599, USA
Award details come from USAspending.gov.
Description
- Abstract
- This proposal builds into our ongoing research in genetics and disease risk in admixed hispanic populations. Hispanics/latinos are the larger racial/ethnic minority in the U.S. They have a high burden of cardiometabolic and inflammatory related diseases. Genetically, hispanics are an heterogenous population comprised of multiple ancestral groups (primarily native american, west african, european) from recent admixture. Few studies have leveraged genetic ancestry to address differences in disease susceptibility. This study will leverage the comprehensive data from the large population-based hispanic community health study/study of latinos for discovery of ancestry-enriched susceptibility loci. We propose to integrate genomics and multi- omics data to map genomic segments and variants inherited from the ancestral population with the higher disease variant frequency (aim 1), use new approaches for fine-mapping genomic regions (aim 2), and validate our findings for clinical relevance in hispanics/latinos from the all of US study (aim 3). We expect to gain insights into the identified ancestry-related genomic regions and variants and their relationship to disease states. This proposal uniquely complements large ongoing genome wide association approaches. Our results may provide insights into differences in disease risk in admixed populations. Ultimately this research could inform personalized medicine and improve public health.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $695,047 | |
| Amendment | $699,000 | |
| Amendment | $699,000 | |
| Amendment | $189,700 | |
| Amendment | $707,304 | |
| Original award | $707,304 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Beth Israel Deaconess Medical Center, Inc. | $195,007 | |
| Regents Of The University Of Minnesota | $880,433 |
Quick answers
Who received award R01HG013163?
R01HG013163 was awarded to University Of North Carolina At Chapel Hill by National Human Genome Research Institute (National Institutes of Health) on August 1, 2024.
How much is award R01HG013163 worth?
$3,697,355 has been obligated on R01HG013163.
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