Project Grant R21HD123376
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $297,252 on September 21, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the impact of chromosome 21 dosage on the placenta secretome and neurodevelopment in Down syndrome. The research examines whether placental abnormalities contribute to altered cortical development in individuals with Down syndrome (trisomy 21). The project uses...
- The National Institute of Child Health and Human Development awarded the University of Wisconsin - Madison $122,361 on January 31, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the mechanisms of reduced neuron generation in Down syndrome. The research evaluates how an extra copy of human chromosome 21 causes reduced cortical size and neuron formation during development. The work focuses on neural progenitor cell behavior during...
- The National Institute of Child Health and Human Development awarded ST Jude Children's Research Hospital Inc. $370,000 on August 17, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to analyze chromosome 21 nondisjunction errors in Down syndrome using a computational framework called MeiHMM. The research applies MeiHMM—a computational method that infers the type of nondisjunction error using only proband genomic data—to approximately 4,500...
- The National Institute of Child Health and Human Development awarded Beth Israel Deaconess Medical Center $724,852 on September 1, 2026, under CFDA 93.865 (Child Health and Human Development Extramural Research) to investigate lymphatic pathology caused by dysregulated NFATC1 signaling using Down syndrome as a model. The research will examine how increased dosage of chromosome 21 genes DYRK1A and DSCR1 drives NFATC1 hyperphosphorylation and functional suppression, disrupting lymphatic...
- This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $429,000 to the Regents of the University of Michigan to conduct research on the molecular regulators of the GABAergic system in human neurons derived from control and trisomy 21 (Down syndrome) human embryonic stem cells. The primary goal is to discover the underlying mechanisms that cause...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded $845,935 to the Research Institute At Nationwide Children's Hospital on July 21, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to establish a single-cell and spatial atlas of trisomy 21 hearts using both Down syndrome mouse models and patient-specific induced pluripotent stem cells. The award funds research aimed at elucidating cellular and tissue mechanisms of septal...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Wisconsin System $568,615 on September 2, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the molecular mechanisms underlying synaptic deficiency in Down syndrome. The research project, titled "Molecular Mechanisms Underlying Synaptic Deficiency in Down Syndrome" (R01HD120347), will use isogenic trisomy 21 disorder-specific human...
- The National Institutes of Health (NIH) Office of the Director awarded a Project Grant of $1,896,457.00 under the Trans-NIH Research Support program (CFDA 93.310) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for the project "BRAIN DEVELOPMENT IN DOWN SYNDROME DURING FETAL AND EARLY POSTNATAL AGES". The grant, awarded on Sep 18, 2024, aims to confirm earlier findings on brain abnormalities in Down syndrome (DS) using advanced...
- The National Institutes of Health Office of the Director awarded the University of New Mexico Health Sciences Center $419,375 on July 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate mechanisms of vascular dysfunction in Down syndrome. The research examines endothelial dysfunction and glycocalyx depletion in a mouse model of Down syndrome (TCMAC21 mice) to understand cardiovascular disease risk in the Down syndrome population. The study investigates how...
- The National Institutes of Health Office of the Director awarded The Regents of The University of Colorado (doing business as University of Colorado-Denver) $312,000 on July 15, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate clonal mosaicism of the hematopoietic system in individuals with Down syndrome. The research examines how clonal selection and cellular composition changes in blood relate to aging and disease risk, with particular focus on clonal...
The National Institute of Child Health and Human Development awarded the University of Connecticut Health Center $457,875 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and deploy an inducible gene dosage correction system in Down syndrome organoid and rodent models carrying human chromosome 21. The research uses an XIST-based transgene system to reversibly silence one copy of chromosome 21 across multiple cell types, including induced pluripotent stem cells, neurons, and astrocytes. The project employs this system as a developmental tool to delineate intervention windows in brain-region-specific organoids and assess the neuronal and cellular benefits of chromosome 21 gene silencing, aiming to clarify which Down syndrome phenotypes remain amenable to therapeutic intervention after development completes and which gene targets and pathways would best suit interventions. The period of performance runs from September 1, 2026, through August 31, 2028. Work is performed in Farmington, Connecticut. The award is classified as a Project Grant, an assistance type under NICHD's extramural research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $457.9k | 9/2/26 |