This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $429,000.00 to the Regents of the University of Michigan to conduct research on the molecular mechanisms underlying changes in inhibitory synapses in Down syndrome. The goal of the project is to discover how the overexpression of the Down Syndrome Cell Adhesion Molecule (DSCAM) gene, resulting from trisomy 21, leads to dysregulation of GABAergic interneuron development and synaptogenesis in human trisomy 21 cell models. The research aims to provide critical insights into the pathogenesis of Down syndrome-related neurological conditions, such as intellectual disability, autism, epilepsy, and Alzheimer's disease, which are associated with dysregulated GABAergic synaptic function. The project will leverage the combined expertise of the Smith and Ye research labs at the University of Michigan to advance the understanding of molecular regulators of the GABAergic system in human neurons, with the potential to inform the development of targeted therapeutic treatments for Down syndrome-related neurological disorders.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $429.0k | 9/11/24 |