Project Grant R03HD123288
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $297,252 on September 21, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the impact of chromosome 21 dosage on the placenta secretome and neurodevelopment in Down syndrome. The research examines whether placental abnormalities contribute to altered cortical development in individuals with Down syndrome (trisomy 21). The project uses...
- The National Institute of Child Health and Human Development awarded the University of Connecticut Health Center $457,875 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and deploy an inducible gene dosage correction system in Down syndrome organoid and rodent models carrying human chromosome 21. The research uses an XIST-based transgene system to reversibly silence one copy of chromosome 21 across multiple cell types,...
- The National Institute of Child Health and Human Development awarded Beth Israel Deaconess Medical Center $724,852 on September 1, 2026, under CFDA 93.865 (Child Health and Human Development Extramural Research) to investigate lymphatic pathology caused by dysregulated NFATC1 signaling using Down syndrome as a model. The research will examine how increased dosage of chromosome 21 genes DYRK1A and DSCR1 drives NFATC1 hyperphosphorylation and functional suppression, disrupting lymphatic...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded $845,935 to the Research Institute At Nationwide Children's Hospital on July 21, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to establish a single-cell and spatial atlas of trisomy 21 hearts using both Down syndrome mouse models and patient-specific induced pluripotent stem cells. The award funds research aimed at elucidating cellular and tissue mechanisms of septal...
- The National Institute of Child Health and Human Development awarded the University of Wisconsin - Madison $122,361 on January 31, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the mechanisms of reduced neuron generation in Down syndrome. The research evaluates how an extra copy of human chromosome 21 causes reduced cortical size and neuron formation during development. The work focuses on neural progenitor cell behavior during...
- The National Institutes of Health Office of the Director awarded The Regents of The University of Colorado (doing business as University of Colorado-Denver) $312,000 on July 15, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate clonal mosaicism of the hematopoietic system in individuals with Down syndrome. The research examines how clonal selection and cellular composition changes in blood relate to aging and disease risk, with particular focus on clonal...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded ST Jude Children's Research Hospital Inc. $690,296 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate nuclear condensation and chromatin reorganization during cerebellar granule neuron differentiation. The research employs three integrated approaches: innovative CMAP epigenetic imaging probes to...
- The National Institutes of Health Office of the Director awarded Ann & Robert H Lurie Children's Hospital of Chicago $448,860 on August 21, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to co-design a digital care pathway that improves primary care clinician adherence to pediatric Down syndrome health supervision guidelines. The project will develop a scalable digital pathway to facilitate clinician implementation of evidence-based Down syndrome screening, early treatment,...
- Federal Project Grant Award Summary Boston Children's Hospital received a $1.27 million Project Grant (R01) from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective August 1, 2025 through July 31, 2027. The award supports collaborative research investigating the mechanisms through which transposable element (TE) mobilization and disrupted messenger RNA (mRNA) translation impair neural progenitor cell (NPC)...
- This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $429,000 to the Regents of the University of Michigan to conduct research on the molecular regulators of the GABAergic system in human neurons derived from control and trisomy 21 (Down syndrome) human embryonic stem cells. The primary goal is to discover the underlying mechanisms that cause...
The National Institute of Child Health and Human Development awarded ST Jude Children's Research Hospital Inc. $370,000 on August 17, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to analyze chromosome 21 nondisjunction errors in Down syndrome using a computational framework called MeiHMM. The research applies MeiHMM—a computational method that infers the type of nondisjunction error using only proband genomic data—to approximately 4,500 Down syndrome individuals with whole-genome sequencing data from the KidsFirst and INCLUDE initiatives. The project describes the prevalence and pattern of nondisjunction errors in Down syndrome and investigates associations between nondisjunction error type and the molecular heterogeneity of Down syndrome-associated acute lymphoblastic leukemia and acute myeloid leukemia. The work will generate a resource cataloging chromosome 21 nondisjunction errors to enable studies of their role in Down syndrome-related conditions, with potential implications for understanding the biological basis of Down syndrome-associated leukemia and other diseases. Performance occurs in Memphis, Tennessee, with completion scheduled for July 31, 2028. This is a project grant, the assistance type for short-term, focused research support from NIH.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $370.0k | 8/19/26 |