Project Grant R01HD119808
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $3,481,644 on August 1, 2026, under the Aging Research program (CFDA 93.866) to investigate mechanisms by which excessive amyloid-beta peptides impair brain lymphatic function and contribute to Alzheimer's disease and Down syndrome. The research program comprises three strategic aims. The first involves extensive molecular, cellular, structural, and functional analyses of brain lymphatics in mouse models of...
- The National Institutes of Health Office of the Director awarded the University of New Mexico Health Sciences Center $419,375 on July 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate mechanisms of vascular dysfunction in Down syndrome. The research examines endothelial dysfunction and glycocalyx depletion in a mouse model of Down syndrome (TCMAC21 mice) to understand cardiovascular disease risk in the Down syndrome population. The study investigates how...
- The National Institute of Child Health and Human Development awarded the University of Wisconsin - Madison $122,361 on January 31, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the mechanisms of reduced neuron generation in Down syndrome. The research evaluates how an extra copy of human chromosome 21 causes reduced cortical size and neuron formation during development. The work focuses on neural progenitor cell behavior during...
- The National Institutes of Health Office of the Director awarded Ann & Robert H Lurie Children's Hospital of Chicago $448,860 on August 21, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to co-design a digital care pathway that improves primary care clinician adherence to pediatric Down syndrome health supervision guidelines. The project will develop a scalable digital pathway to facilitate clinician implementation of evidence-based Down syndrome screening, early treatment,...
- The National Institute of Child Health and Human Development awarded the University of Connecticut Health Center $457,875 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and deploy an inducible gene dosage correction system in Down syndrome organoid and rodent models carrying human chromosome 21. The research uses an XIST-based transgene system to reversibly silence one copy of chromosome 21 across multiple cell types,...
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $297,252 on September 21, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the impact of chromosome 21 dosage on the placenta secretome and neurodevelopment in Down syndrome. The research examines whether placental abnormalities contribute to altered cortical development in individuals with Down syndrome (trisomy 21). The project uses...
- The National Institutes of Health (NIH) Office of the Director awarded a Project Grant of $1,896,457.00 under the Trans-NIH Research Support program (CFDA 93.310) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for the project "BRAIN DEVELOPMENT IN DOWN SYNDROME DURING FETAL AND EARLY POSTNATAL AGES". The grant, awarded on Sep 18, 2024, aims to confirm earlier findings on brain abnormalities in Down syndrome (DS) using advanced...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded $845,935 to the Research Institute At Nationwide Children's Hospital on July 21, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to establish a single-cell and spatial atlas of trisomy 21 hearts using both Down syndrome mouse models and patient-specific induced pluripotent stem cells. The award funds research aimed at elucidating cellular and tissue mechanisms of septal...
- The National Institute of Child Health and Human Development awarded Trustees of Boston University $131,694 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to characterize neural correlates of motor skill development in children with Down syndrome. The research uses upper extremity reaching as a model motor behavior to identify associations between reaching kinematics and brain activity in two pediatric cohorts. During the two-year...
- The National Institutes of Health Office of the Director awarded Virginia Commonwealth University $378,519 under the Trans-NIH Research Support program (CFDA 93.310) on August 7, 2026, to investigate how alterations in DYRK1A dosage affect craniofacial development and to uncover the mechanisms through which changes in this protein influence cell cycle, senescence, and cell survival. The work addresses birth defects associated with both Down syndrome, where excess DYRK1A occurs on chromosome...
The National Institute of Child Health and Human Development awarded Beth Israel Deaconess Medical Center $724,852 on September 1, 2026, under CFDA 93.865 (Child Health and Human Development Extramural Research) to investigate lymphatic pathology caused by dysregulated NFATC1 signaling using Down syndrome as a model. The research will examine how increased dosage of chromosome 21 genes DYRK1A and DSCR1 drives NFATC1 hyperphosphorylation and functional suppression, disrupting lymphatic endothelial cell identity and lymphatic development. The project will define how NFATC1 suppression alters the NFATC1-PROX1-COUP-TFII transcriptional module in human and mouse Down syndrome lymphatic endothelial cells using transcriptomic and molecular analyses across developmental stages. The team will determine how increased DYRK1A/DSCR1 dosage shapes meningeal lymphatic architecture and function in vivo through gene dosage normalization in mouse models and will employ a lymphatics-on-chip platform to quantify effects on lymphatic endothelial cell sprouting, valve gene programs, junctional organization, and drainage behavior under defined flow conditions. The project will test a mechanotransduction-based rescue strategy activating PIEZO1-controlled mechanotransduction to restore impaired brain fluid drainage, with the goal of establishing a mechanistically guided therapeutic approach to lymphatic dysfunction. Performance is located in Boston, Massachusetts, with a period of performance through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $724.9k | 8/27/26 |