Project Grant R24HL184948
- The National Institute of Child Health and Human Development awarded Beth Israel Deaconess Medical Center $724,852 on September 1, 2026, under CFDA 93.865 (Child Health and Human Development Extramural Research) to investigate lymphatic pathology caused by dysregulated NFATC1 signaling using Down syndrome as a model. The research will examine how increased dosage of chromosome 21 genes DYRK1A and DSCR1 drives NFATC1 hyperphosphorylation and functional suppression, disrupting lymphatic...
- The National Institutes of Health Office of the Director awarded the University of New Mexico Health Sciences Center $419,375 on July 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate mechanisms of vascular dysfunction in Down syndrome. The research examines endothelial dysfunction and glycocalyx depletion in a mouse model of Down syndrome (TCMAC21 mice) to understand cardiovascular disease risk in the Down syndrome population. The study investigates how...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Indiana University Indianapolis $692,850 on July 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop new Down syndrome mouse models that clarify sex-specific co-occurring phenotypes associated with Trisomy 21. The project creates the first systematic determination of the sources of sex differences in Down syndrome phenotypes using offspring from DP16 × Four Core...
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $297,252 on September 21, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the impact of chromosome 21 dosage on the placenta secretome and neurodevelopment in Down syndrome. The research examines whether placental abnormalities contribute to altered cortical development in individuals with Down syndrome (trisomy 21). The project uses...
- The National Institute of Child Health and Human Development awarded the University of Connecticut Health Center $457,875 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and deploy an inducible gene dosage correction system in Down syndrome organoid and rodent models carrying human chromosome 21. The research uses an XIST-based transgene system to reversibly silence one copy of chromosome 21 across multiple cell types,...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Wisconsin System $568,615 on September 2, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the molecular mechanisms underlying synaptic deficiency in Down syndrome. The research project, titled "Molecular Mechanisms Underlying Synaptic Deficiency in Down Syndrome" (R01HD120347), will use isogenic trisomy 21 disorder-specific human...
- Federal Project Grant Award Summary Boston Children's Hospital received a $1.27 million Project Grant (R01) from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective August 1, 2025 through July 31, 2027. The award supports collaborative research investigating the mechanisms through which transposable element (TE) mobilization and disrupted messenger RNA (mRNA) translation impair neural progenitor cell (NPC)...
- The National Institutes of Health Office of the Director awarded Ann & Robert H Lurie Children's Hospital of Chicago $448,860 on August 21, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to co-design a digital care pathway that improves primary care clinician adherence to pediatric Down syndrome health supervision guidelines. The project will develop a scalable digital pathway to facilitate clinician implementation of evidence-based Down syndrome screening, early treatment,...
- The Children's Hospital of Philadelphia Research Institute received a $289,158 Project Grant awarded on September 15, 2025, under the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) to conduct the CASCADE (Cardiometabolic Risk and Comorbidities in Adults with Down Syndrome—Electronic Health Record Examination) study. This research initiative will deliver a comprehensive epidemiological analysis of cardiometabolic risk factors in adults with Down...
- The National Institutes of Health (NIH) Office of the Director awarded a Project Grant of $1,896,457.00 under the Trans-NIH Research Support program (CFDA 93.310) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for the project "BRAIN DEVELOPMENT IN DOWN SYNDROME DURING FETAL AND EARLY POSTNATAL AGES". The grant, awarded on Sep 18, 2024, aims to confirm earlier findings on brain abnormalities in Down syndrome (DS) using advanced...
The Department of Health and Human Services National Institutes of Health Office of the Director awarded $845,935 to the Research Institute At Nationwide Children's Hospital on July 21, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to establish a single-cell and spatial atlas of trisomy 21 hearts using both Down syndrome mouse models and patient-specific induced pluripotent stem cells. The award funds research aimed at elucidating cellular and tissue mechanisms of septal defects in Down syndrome by deep phenotyping of patient-specific induced pluripotent stem cell-derived atrioventricular canal cardioids and trisomy 21 mouse models using cutting-edge single-cell and spatial transcriptomics. The project leverages two genetically engineered mouse lines—DP1TYB (triplication of MMU16) and TCMAC21 (transchromosomic HSA21)—that recapitulate cardiac structural defects with high penetrance, alongside in vitro cardioid models derived from affected patients' cells to understand how trisomy 21 disrupts early cardiac cell lineage differentiation and contributes to congenital heart defects. Work is performed in Columbus, Ohio. The period of performance runs through May 31, 2030. This is a project grant, a standard NIH assistance mechanism subject to peer review on scientific merit and program relevance, with performance subject to OMB 2 CFR 200 audit requirements and standard NIH record retention and access provisions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $845.9k | 7/22/26 |