Project Grant R21HD122979
- The National Institute of Child Health and Human Development awarded The Trustees of Columbia University in the City of New York $444,824 on August 20, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to engineer human pluripotent stem cell (HPSC)-derived endometrial organoids for modeling regeneration and disease mechanisms. The project will develop an innovative platform that recapitulates physiological interactions and developmental trajectories...
- The National Institute of Child Health and Human Development awarded Duke University $581,258 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate transposable elements as mechano-response enhancer elements regulating human embryonic stem cell fate. The research examines how mechanical forces regulate transposable element sequences that control gene expression and pluripotent stem cell differentiation. The project tests three...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services National Institutes of Health, awarded $456,500 to The University of Texas Southwestern Medical Center on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds molecular characterization of human pregnancy-induced cervical epithelium through two research aims. First, the recipient will apply single-cell and spatial...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- The National Institute of Child Health and Human Development awarded Duke University $694,448 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research analyzing local and global responses in the placenta syncytiotrophoblast. The research investigates the multinucleated syncytiotrophoblast, a giant single cell that separates maternal and fetal vasculature during pregnancy and performs critical functions including nutrient...
- The National Institute of Child Health and Human Development awarded the University of California, Santa Barbara $123,957 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) for research into how mechanical forces coordinate cell movements during vertebrate gastrulation, specifically examining the Spemann-Mangold organizer's role in establishing germ layers and embryonic axes. The funded research develops and applies...
- The National Institute of Child Health and Human Development awarded Baylor College of Medicine $596,684 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate co-transcriptional regulation mechanisms controlling human cell fate during early embryogenesis. The research defines the developmental and mechanistic roles of the protein ILF3 in primate-specific cell fate transitions. The work uses cross-species gastruloid models derived...
- The National Institute of Child Health and Human Development awarded the University of Missouri System $411,539 on May 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct functional assessment of extracellular vesicles from the female reproductive tract during early pregnancy. The research uses oviductal epithelial cell-specific CD9-green fluorescent protein reporter mice to visualize and track maternal extracellular vesicles within...
- The National Institute of Child Health and Human Development awarded California Institute of Technology $128,331 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the hydraulic regulation of human gastrulation and mesodermal patterning using stem cells. The research employs a novel three-dimensional stem cell-based model termed "lumenoids" to dissect mechanobiological principles underlying early...
- Yale University received a $460,625 Project Grant award dated August 11, 2025, from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research initiative, with a completion date of July 31, 2027, focuses on elucidating the mechanisms of hematopoietic stem cell (HSC) development during fetal life in mice. The project addresses critical gaps in understanding how endothelial cells...
The National Institute of Child Health and Human Development awarded the University of Florida $422,125 on August 12, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to dissect mechanisms of pre-implantation embryonic and extraembryonic lineage crosstalk using bovine stem cell models as a proxy for human development. The research establishes bovine embryo-derived stem cell lines including naive-like embryonic stem cells, trophoblast stem cells, and extraembryonic endoderm stem cells, and develops integrated bovine blastoids through assembly of embryonic and extraembryonic stem cells to test hypotheses relevant to lineage crosstalk in vitro. This work addresses a fundamental knowledge gap in molecular and cellular mechanisms of human embryogenesis and pregnancy loss, leveraging bovine blastoids as a controlled cellular substrate that resembles human blastocyst development in morphology, size, cell number, marker gene expression, and lineage composition. Performance takes place in Gainesville, Florida, with a period of performance from August 12, 2026, through July 31, 2028. The award is classified as a Project Grant, the standard NIH R21 mechanism supporting exploratory high-risk, high-reward research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $422.1k | 8/13/26 |