Project Grant R21HD120966
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $153,560 on December 1, 2026, under the Child Health and Human Development Extramural Research Program (CFDA 93.865) to investigate gene regulatory mechanisms driving totipotency induction in human stem cells. The research examines how RNA splicing dysfunction alters early human development through integrative transcriptomic, epigenomic, and proteomic profiling. The work focuses on...
- The National Institute of Child Health and Human Development awarded California Institute of Technology $100,228 on December 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research identifying molecular and structural cues introduced at fertilization that influence early cell fate biases in the mammalian embryo. The research traces how sperm-derived components and the second polar body establish asymmetries as early as the 2-cell stage,...
- The National Institute of Child Health and Human Development awarded the University of Southern California $347,919 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR) to decipher the role of RG motifs in piRNA-mediated silencing and transgenerational fertility. The research investigates how arginine/glycine (RG) motifs in PIWI-interacting RNA (piRNA) pathway proteins PRG-1 and HRDE-1 regulate germline gene expression...
- The National Institute of Child Health and Human Development awarded Trustees of Dartmouth College $450,250 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how three RNA-binding proteins—PATL2, PUM1, and PUM2—regulate translational control during oocyte meiosis and early embryogenesis in a mouse model. The research uses cutting-edge technologies to define the unique and shared mRNA targets of these proteins and determine...
- The National Institute of Child Health and Human Development awarded the University of Massachusetts $157,427 on May 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of maternal MCM4 protein in zygotic DNA replication and the oocyte-to-embryo transition. The research uses live imaging, immunofluorescence, and RNA sequencing to examine how maternal MCM4 governs zygotic replication and mitotic fidelity in oocyte-specific...
- The National Institute of Child Health and Human Development awarded University of California Irvine $233,528 on September 27, 2025, under the Child Health and Human Development Extramural Research (CFDA 93.865) program to support research on gene regulatory redundancy in mammalian development. The recipient will conduct experimental work to identify distinct transcription factors driving shadow enhancers—redundant non-coding DNA elements that control gene expression during development—and...
- The National Institute of Child Health and Human Development awarded $668,485 to the University of California, San Diego on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate DNA repair mechanisms in hypoxia-induced placental genomic instability. The research examines increased genomic instability in placental villous tissue and trophoblast stem cells associated with maternal vascular malperfusion, a pattern of placental...
- The National Institute of Child Health and Human Development awarded The Regents of the University of California, San Francisco $123,147 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds research investigating granulosa-derived RNAs as targets for oocyte rejuvenation and age-related oocyte quality infertility. The project comprises three aims: interrogating the mechanism by which RNAs transfer from granulosa cells to...
- The National Institute of Child Health and Human Development awarded the University of California, Santa Barbara $123,957 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) for research into how mechanical forces coordinate cell movements during vertebrate gastrulation, specifically examining the Spemann-Mangold organizer's role in establishing germ layers and embryonic axes. The funded research develops and applies...
- The National Institute of Child Health and Human Development awarded Baylor College of Medicine $149,190 on January 1, 2026, to conduct research on microRNA-290's role in regulating maternal-fetal nutrient exchange during neural tube closure under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research investigates how microRNA-290 expressed in extraembryonic tissues, including the yolk sac, affects nutrient transport to embryos during early pregnancy...
The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse preimplantation embryos, with two primary aims: investigating METTL7A1's role in minor zygotic genome activation and preimplantation development, and identifying RNA targets and modifications catalyzed by the enzyme. Work is performed in Santa Cruz, California, over the period of August 1, 2026 through July 31, 2028. The award is classified as a Project Grant, a form of research assistance funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $430.4k | 7/31/26 |