Project Grant R21HD119276
- Federal Project Grant Award Summary The University of Missouri System received a $153,675 project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded May 15, 2026, with completion targeted for April 30, 2028. This research initiative investigates progesterone receptor (PGR) signaling in oviductal ciliated cells and its role in maintaining reproductive longevity. The project...
- Federal Project Grant Award Summary The University of Missouri System received a $413,118 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through June 30, 2030. This five-year award supports fundamental research investigating organelle transport and organization mechanisms in mammalian oogenesis, with specific focus on how primary oocytes are determined during...
- Federal Grant Award Summary The University of Missouri System received a $166,310 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) for the period September 1, 2025 through August 31, 2027. The research project, titled "Intergenerational Socioeconomic and Health Effects of Family Support Programs," examines the long-term impacts of welfare program withdrawal...
- Federal Project Grant Award Summary The University of Kansas Medical Center Research Institute, Inc. received a $426,250 Project Grant award dated August 6, 2025, from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research through July 31, 2027, investigating the role of Protein Arginine Methyltransferase 1 (PRMT1) in regulating trophoblast development and...
- Federal Project Grant Summary The National Institute of Child Health and Human Development (NICHD) awarded The Washington University a $657,377 Project Grant effective September 1, 2025, through May 31, 2030, under the Child Health and Human Development Extramural Research program (CFDA 93.865). This award funds research to advance understanding of human trophoblast development and function using pluripotent stem cell models. The research addresses critical gaps in knowledge regarding...
- Federal Grant Award Summary The University of Michigan received a $390,504 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective June 1, 2026 through February 28, 2031. This award funds research to advance understanding of human primordial germ cell (hPGC) differentiation from human pluripotent stem cells, with applications toward in vitro gametogenesis and...
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded Columbia University's Health Sciences Division a $719,141 Project Grant (CFDA 93.865: Child Health and Human Development Extramural Research) on August 11, 2025, to conduct a longitudinal study leveraging in vitro fertilization (IVF) to identify prenatal programming effects independent of shared maternal-child genes. The research will test the Developmental Origins of Health and...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded The Washington University a Project Grant of $125,142 under the Child Health and Human Development Extramural Research program (CFDA 93.865) effective June 1, 2026, through May 31, 2028. This award funds research investigating the impact of bacterial vaginosis (BV) toxins on sperm function and fertility. The research will elucidate the molecular mechanisms by which BV-associated toxins,...
- The University of Missouri System received a $165,787 Project Grant from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships program (CFDA 47.084), effective October 1, 2025 through October 31, 2026. This Partnerships for Innovation–Mid Career Advancement (PFI-MCA) award supports the development of an innovative 3D cell culture platform technology designed to model the transport of pharmaceutical agents across the placental barrier. The platform integrates...
- Federal Grant Award Summary Saint Louis University received a $1,296,204 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 1, 2025, with completion targeted for May 31, 2030. The award funds investigator-initiated research examining the role of the GPR173 receptor and its ligand phoenixin (PNX) in regulating plasma volume expansion during pregnancy....
Federal Project Grant Summary The University of Missouri System received a $411,539 project grant awarded May 15, 2026, from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). This research initiative focuses on investigating the functional significance of extracellular vesicles (EVs) from the female reproductive tract during early pregnancy and their role in embryo-maternal communication. The project, scheduled for completion by March 31, 2028, leverages innovative transgenic mouse models with oviductal epithelial cell-specific CD9-green fluorescent protein reporter technology to directly visualize and track maternal EVs within preimplantation embryos in vivo. The research project delivers two complementary research products: (1) a comprehensive mapping of EV distribution and miRNA cargo profiling across oviductal and uterine luminal fluid throughout early pregnancy stages to illuminate dynamic changes in EV-mediated signaling; and (2) functional characterization of epithelial cell-derived EVs through pharmacological inhibitor studies assessing effects on embryo development, implantation, and pregnancy outcomes. These research findings are designed to advance understanding of reproductive biology and improve assisted reproductive technology success rates by elucidating mechanisms of early embryo development and implantation, directly supporting NICHD's mission to enhance reproductive health and optimize outcomes across the lifespan.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $411.5k | 5/7/26 |